The Centers for Disease Control and Prevention (CDC) is forecasting a funding opportunity for the implementation and evaluation of PrEPmate, a mobile health intervention aimed at enhancing HIV pre-exposure prophylaxis (PrEP) adherence among young men who have sex with men (YMSM) and transgender women of color. The initiative seeks to facilitate the deployment of PrEPmate at three clinical sites in the southern United States, focusing on improving patient adherence and retention in PrEP care through tailored interactive content and reminders, while also evaluating the integration of this intervention into clinical services. With an estimated total program funding of $3 million and a single award anticipated, interested applicants can reach out to Charles Collins at the CDC via email at cwc4@cdc.gov or by phone at 404-639-0966. The application process is expected to open with a synopsis posted on January 7, 2025, and close by March 7, 2025, with awards projected to be made by July 1, 2025.