The National Center for Complementary and Integrative Health (NCCIH) is seeking applications for investigator-initiated clinical trials that deliver complementary and integrative health interventions remotely or via mobile health (mHealth) technologies. The funding opportunity, designated as PAR-25-268, emphasizes the need for trials that assess the efficacy or effectiveness of such interventions without in-person interactions between research staff and participants. Successful applications must provide preliminary data supporting the feasibility, safety, and potential clinical benefits of the interventions proposed. Integral to the application process is the requirement for a Plan for Enhancing Diverse Perspectives (PEDP) to foster inclusivity among research participants, especially from diverse and underrepresented backgrounds. Key details include the funding’s alignment with NCCIH's strategic priorities, including research on mind and body interventions, health behavior promotion, and reducing health disparities. Applications are expected to be robust, well-justified designs with rigorous methodology for remote engagement. The timeline indicates open submission beginning January 20, 2025, but applicants are urged to initiate early communications with NCCIH scientific contacts to ensure readiness. This funding opportunity reflects NCCIH's commitment to expanding access to integrative health approaches and addressing public health challenges through innovative research practices.