The National Institutes of Health (NIH) has announced a funding opportunity titled "NIDA REI: Research on Neurocognitive Mechanisms Underlying the Impact of Structural Racism on the Substance Use Trajectory (R61/R33 Clinical Trial Optional)." This initiative aims to support exploratory and developmental clinical research projects that investigate the effects of structural racism on neurocognition and the risk of substance use disorders (SUD), emphasizing innovative approaches that consider both structural and biological factors. The program is designed to promote health equity and reduce disparities among racial and ethnic minority populations, with funding available up to $1.5 million annually for 3-5 projects, each with a budget cap of $500,000 per year. Interested applicants must submit proposals by November 14, 2024, and can direct inquiries to the NIH OER Webmaster at OERWebmaster03@od.nih.gov.