The National Institutes of Health is offering a grant opportunity titled "Mechanistic and Hemodynamic Basis of Diffuse White Matter Disease in Vascular Contributions to Cognitive Impairment and Dementia (VCID)(R01 - Clinical Trial Not Allowed)". This grant aims to address the knowledge gaps in the biologic mechanisms of diffuse white matter disease, which is commonly associated with vascular contributions to cognitive impairment and dementia. Diffuse white matter disease is a prevalent condition in the elderly and is characterized by various pathologies such as demyelination and fiber loss. It is typically detected through imaging techniques like magnetic resonance imaging (MRI) or computed tomography x-ray (CT) scan. The grant seeks to understand the cellular and molecular causes, regional vulnerability, and progression of white matter disease at the molecular, cellular, tissue, and brain circuit level. The ultimate goal is to inform future efforts in reducing the burden of age-related vascular contributions to cognitive impairment and dementia. For more information, visit the grant opportunity page.