Mechanisms that Impact Cancer Risk with Use of Incretin Mimetics (R01 Clinical Trial Optional)
ID: 349964Type: Posted
Overview

Buyer

National Institutes of Health (HHS-NIH11)

Eligible Applicants

Others

Funding Category

Health

Funding Instrument

Grant

Opportunity Category

Discretionary

Cost Sharing or Matching Requirement

Yes

Original Source

https://grants.gov/search-results-detail/349964

Additional Information

http://grants.nih.gov/grants/guide/pa-files/PAR-23-279.html
Timeline
    Description

    The National Institutes of Health (NIH) is offering a funding opportunity titled "Mechanisms that Impact Cancer Risk with Use of Incretin Mimetics (R01 Clinical Trial Optional)" aimed at advancing research on the effects of incretin mimetics on cancer risk. This initiative seeks to promote preclinical and patient-based studies that investigate the mechanisms by which incretin mimetics, including GLP-1 and GIP-1 receptor agonists, may influence cancer risk, particularly in relation to obesity-related cancers such as thyroid and prostate cancers. The funding is intended to support diverse scientific inquiries into cancer biology, with applications encouraged from a wide range of eligible institutions, including historically black colleges, tribal colleges, and community-based organizations. Interested applicants should note that the application submission period opens on January 5, 2024, and the closing date for submissions is January 7, 2027. For further inquiries, applicants can contact NIH Grants Information at grantsinfo@nih.gov or visit the opportunity's webpage at https://grants.nih.gov/grants/guide/pa-files/PAR-23-279.html.

    Point(s) of Contact
    grantsinfo@nih.gov
    Files
    Title
    Posted
    PAR-23-279-Full-Announcement.html
    PAR-23-279.html
    The National Cancer Institute (NCI) is inviting applications for R01 Research Project Grants aimed at understanding how incretin mimetics, specifically glucagon-like peptide (GLP-1) and dual GLP-1/glucose-dependent insulinotropic polypeptide (GIP-1) receptor agonists, influence cancer risk. This funding opportunity focuses on elucidating mechanisms by which these agents could either mitigate or exacerbate cancer risks, particularly for thyroid and prostate cancers. Investigators are encouraged to submit applications that propose studies involving both animal models and human trials, provided they scrutinize specific mechanistic endpoints related to cancer development following incretin mimetic administration. Notably, the opportunity is not meant for epidemiological studies, and the proposal must include rigorous justifications if using incretin mimetics other than GLP-1 RAs. Key application dates are established, with the open date for submissions beginning January 5, 2024. This initiative reflects a commitment to exploring the therapeutic implications of incretin mimetics in oncology, amidst rising obesity-related cancer risks in the U.S., particularly given that obesity is a significant contributor to increased cancer mortality. Overall, the NCI seeks to broaden the understanding of cancer biology relating to incretin mimetics while fostering diverse scientific inquiry in the field.
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