The National Institutes of Health (NIH) has announced a funding opportunity for research into the biology of bladder cancer, designated as the R01 Clinical Trial Optional grant (FOA Number PAR-22-218). This initiative aims to support investigations that explore the underlying mechanisms of bladder cancer, which poses a significant health challenge due to its high incidence and recurrence rates. The program encourages multidisciplinary applications that focus on both normal bladder biology and the alterations associated with cancer, with a strong emphasis on biological research rather than clinical outcomes in muscular invasive bladder cancer. Interested applicants must submit their proposals by September 7, 2025, and can find additional information and application guidelines at the NIH website or contact the NIH OER Webmaster at OERWebmaster03@od.nih.gov for further inquiries.