Engineering Improved Stem Cell-Derived Islet Cells for Replacement Therapies (R01 - Clinical Trial Not Allowed)
Grant Opportunity Analysis
The National Institutes of Health (NIH) has announced a funding opportunity titled "Engineering Improved Stem Cell-Derived Islet Cells for Replacement Therapies (R01 - Clinical Trial Not Allowed)" aimed at advancing research in the engineering of stem cell-derived islet cells specifically for Type 1 Diabetes therapies. This grant seeks to support studies that enhance the intrinsic characteristics of these islet cell products, which are derived from well-defined cell bank sources, to improve graft viability and function through optimized banking, manufacturing, and quality control processes. With an estimated total program funding of $3 million and an award ceiling of $500,000, the NIH anticipates awarding approximately six grants, with applications due by March 7, 2026. For further inquiries, interested applicants can contact Albert Hwa at NIDDK_DEM@nih.gov.
Eligible Applicants
Refer to Section III. Eligibility Information in the NOFO for additional information on eligibility.Foreign Organizations/International CollaborationsNon-domestic (non-U.S.) Entities (Foreign Organizations) are not eligible to apply.Non-domestic (non-U.S.) components of U.S. Organizations are not eligible to apply.Foreign components, as defined in the NIH Grants Policy Statement, are not allowed.NIH will no longer issue awards (i.e., new, renewal, or non-competing continuation) to domestic or foreign entities that involve foreign subawards/subcontracts. All NIH-funded research involving foreign subawards/subcontracts must be submitted in response to a NOFO that is specifically designated for funded international collaborations. This new requirement was effective, May 1, 2025.Applications involving foreign subawards/subcontracts submitted in response to this NOFO will be deemed noncompliant and will not be considered for funding. This policy applies to all monetary international collaborations resulting in foreign subawards/subcontracts, however, it does not preclude unfunded international collaborations or foreign components, funding for foreign consultants, or procurement of unique equipment or supplies from foreign vendors.