The Advanced Research Projects Agency for Health (ARPA-H) has announced the Master Announcement Instructions (MAI), a federal grant opportunity aimed at establishing standardized tiered proposal submission requirements for research and development projects. This initiative is designed to streamline the proposal process, reducing the upfront work needed to submit cost information, thereby lowering barriers for non-traditional performers such as universities, non-profit organizations, and small businesses. Proposals are not to be submitted against the MAI itself but rather against specific Module Announcements linked to it, which will provide detailed instructions tailored to varying levels of effort. Interested applicants can find more information and submit inquiries to the MAI Team at MAIQuestions@arpa-h.gov, with the application deadline set for October 20, 2024.