The Department of Health and Human Services, through the National Institutes of Health (NIH), is offering a funding opportunity (PAR-23-237) aimed at enhancing and managing established biomedical data repositories and knowledgebases. The initiative seeks to support resources that have demonstrated impact, showing potential continued benefits to biomedical research communities. These resources should provide scientific impact, employ good data management practices following FAIR principles, and engage with the research community to address their needs. Applications are encouraged from diverse organizations, including higher education institutions, non-profits, and tribal governments, with a potential award period of up to five years. The NIH emphasizes that only applications for established resources will be accepted, and those proposing early-stage development must apply under a different funding opportunity (PAR-23-236). Key submission dates include an open date of September 30, 2023, with multiple application deadlines extending to November 26, 2025. The review process will assess significance, investigator qualifications, innovation, the effectiveness of the approach, and the scientific environment. Ultimately, the NIH seeks to fortify the data resource ecosystem, promoting collaborative efforts and adherence to best practices in data stewardship.