The National Institutes of Health (NIH) is offering a funding opportunity for the development of early-stage biomedical data repositories and knowledgebases through the R24 grant mechanism, which does not permit clinical trials. This initiative aims to enhance the biomedical research community's capabilities by supporting the establishment of new data resources or significant modifications to existing ones, adhering to the FAIR data principles. The funding opportunity is crucial for building a modernized biomedical data ecosystem, with a maximum budget of $350,000 per year available for projects lasting up to four years. Interested applicants, including a wide range of institutions such as higher education entities and nonprofits, must submit their applications by January 25, 2026, and can find more information at the NIH grants website or contact grantsinfo@nih.gov for inquiries.