The National Institutes of Health (NIH) is inviting proposals for the funding opportunity titled "Imaging, Biomarkers and Digital Pathomics for the Early Detection of Premetastatic Cancer and Precancerous Lesions Associated with Lethal Phenotypes." This initiative aims to support innovative projects that integrate advanced imaging technologies, biomarkers, and multi-omic data to enhance the early detection of aggressive cancers and precancerous lesions, thereby improving diagnostic sensitivity and specificity. The program is crucial for addressing diagnostic uncertainties in clinical settings and aims to reduce overdiagnosis and false results in cancer screenings. Eligible applicants include a wide range of organizations, such as higher education institutions and nonprofits, with project budgets reflecting actual needs over a maximum duration of five years. Interested parties should submit their applications by September 7, 2025, and can direct inquiries to the NIH OER Webmaster at OERWebmaster03@od.nih.gov. For more details, visit the official announcement at http://grants.nih.gov/grants/guide/pa-files/PAR-22-131.html.