The Department of Health and Human Services is issuing a Notice of Funding Opportunity (NOFO) for the Rare Diseases Clinical Research Consortia (RDCRC) as part of the Rare Diseases Clinical Research Network (RDCRN). This initiative aims to foster collaborative, multi-site clinical research focused on advancing diagnosis and treatment for diverse rare diseases affecting fewer than 200,000 individuals in the U.S. The program encourages applications for both new and renewal projects, emphasizing patient-centered research and the need for early diagnosis and clinical trial readiness. Key components of the RDCRCs include forming partnerships with patient advocacy groups, conducting longitudinal studies, and leveraging technologies to enhance therapeutic development. The funding opportunity is structured around several cores, including Administrative, Clinical Research, and Data Management, ensuring coordinated efforts across the network. Applicants must engage actively with the Coalition of Patient Advocacy Groups and align research initiatives with specific NIH Institute priorities. The RDCRN has already supported numerous projects that have led to significant findings and FDA treatment approvals. This funding opportunity seeks to build upon those successes to improve health outcomes and enhance the understanding of rare diseases through innovative research methodologies and collaborative networks.