The Department of Health and Human Services, specifically through the National Institutes of Health (NIH), has issued a funding opportunity aimed at leveraging health information technology (health IT) to reduce health disparities in the U.S. This initiative targets populations historically affected by such disparities, including racial and ethnic minorities, socioeconomically disadvantaged groups, and other vulnerable communities. The program encourages multidisciplinary research that examines the effects of health IT on various aspects of healthcare, including access, quality of care, communication between patients and clinicians, and overall health outcomes. Applicants are encouraged to integrate social determinants of health into their research designs and to consider innovative health IT solutions that promote equity, particularly in light of challenges posed by the COVID-19 pandemic. The NIH will support projects from a wide array of organizations, including higher education institutions, nonprofits, and local governments. The application process involves a detailed proposal submission through established NIH channels, emphasizing adherence to grant application guidelines and review criteria. Overall, this funding opportunity seeks to enhance health equity by promoting research that effectively utilizes health IT to address and diminish existing healthcare disparities across vulnerable populations.