The Centers for Disease Control and Prevention (CDC) is forecasting a cooperative agreement opportunity aimed at transitioning health information systems (HIS) to country ownership, optimizing digital health strategies to achieve HIV/AIDS and TB epidemic control by 2030 under the PEPFAR initiative. This initiative seeks to enhance local capacity through the development of country-owned HIS, governance frameworks, and a skilled health informatics workforce, while also focusing on data-driven solutions and partnerships to support marginalized populations. The estimated total funding for the first year is approximately $25 million, with five awards anticipated, and applications must be submitted electronically by February 17, 2025, to be considered. For further inquiries, interested applicants can contact Emily Dale at (404) 639-8880 or via email at pepfarfoas@cdc.gov.