The National Institutes of Health (NIH) plans to publish a funding opportunity announcement for the Understanding the Intersection of Social Inequities to Optimize Health and Reduce Health Disparities: The Axes Initiative (R01 Clinical Trial Optional). This initiative aims to address social inequities and reduce health disparities. The funding opportunity will utilize the R01 activity code. Potential applicants are encouraged to develop collaborations and projects that align with this initiative. The estimated synopsis post date is April 26, 2024, and the estimated synopsis close date is July 5, 2024. The estimated award and project start date is April 1, 2025.