The National Institutes of Health (NIH) is preparing to reissue a Notice of Funding Opportunity (NOFO) for the Mentored Research Career Development Program Award under the Clinical and Translational Science Awards (CTSA) Program, designated as K12 Clinical Trial Optional. This initiative aims to foster meaningful collaborations and responsive projects in clinical and translational science, providing support for institutional research career development. The anticipated NOFO is expected to be published in Summer 2024, with applications due by January 2025, and awards projected to be made by December 2025. Interested applicants should prepare to align their proposals with the program's objectives and timelines.