The National Institutes of Health (NIH) is preparing to publish a Notice of Funding Opportunity (NOFO) for the NCI Pathway to Independence Award (K99/R00), which includes an optional independent clinical trial component. This program aims to support the transition of talented postdoctoral researchers, who have up to six years of postdoctoral research training experience, into independent tenure-track faculty positions, thereby fostering a strong cohort of independent investigators in cancer research. The funding opportunity is significant as it provides essential support for awardees to establish competitive, independent research careers aligned with the mission of the National Cancer Institute (NCI). Interested applicants should note that the estimated synopsis post date is November 1, 2024, with a closing date for applications on February 14, 2025, and an anticipated award date of January 2, 2026.