The National Institutes of Health (NIH) is offering a grant opportunity titled "Discovery of the Genetic Basis of Childhood Cancers and of Structural Birth Defects: Gabriella Miller Kids First Pediatric Research Program (X01 Clinical Trial Not Allowed)". This grant aims to support the discovery of the genetic basis of childhood cancers and structural birth defects through the Gabriella Miller Kids First Pediatric Research Program. The program encourages the submission of samples from pediatric cohorts for whole genome sequencing at a Kids First Program-supported sequencing center. The goal is to elucidate the genetic contribution to childhood cancers, investigate the genetic etiology of structural birth defects, study the molecular basis of the associations between birth defects and increased cancer risk, and expand the range of pediatric disorders included within the Kids First Data Resource. The program accepts proposals for whole genome, exome, and transcriptome sequencing, as well as epigenomic assays of tumor or affected tissue. Applicants are encouraged to propose cohorts of underrepresented racial and ethnic groups or increase representation in existing Kids First Program projects. The data, along with associated clinical and phenotypic data, will be shared with the research community through the Kids First Data Resource Center. For more information and to apply, visit the NIH grants website at http://grants.nih.gov/grants/guide/pa-files/PAR-24-082.html.