Discovery of the Genetic Basis of Childhood Cancers and of Structural Birth Defects: Gabriella Miller Kids First Pediatric Research Program (X01 Clinical Trial Not Allowed)

Active
No
Status
Posted
Published Date
December 12th, 2023
Close Date
March 13th, 2024
Opportunity No.
PAR-24-082

Agency

National Institutes of Health (HHS-NIH11)

Eligible Applicants

Others

Funding Category

Health

Funding Instrument

Grant

Opportunity Category

Discretionary

Cost Sharing or Matching Requirement

Yes

Summary

The National Institutes of Health (NIH) is offering a grant opportunity titled "Discovery of the Genetic Basis of Childhood Cancers and of Structural Birth Defects: Gabriella Miller Kids First Pediatric Research Program (X01 Clinical Trial Not Allowed)". This grant aims to support the discovery of the genetic basis of childhood cancers and structural birth defects through the Gabriella Miller Kids First Pediatric Research Program. The program encourages the submission of samples from pediatric cohorts for whole genome sequencing at a Kids First Program-supported sequencing center. The goal is to elucidate the genetic contribution to childhood cancers, investigate the genetic etiology of structural birth defects, study the molecular basis of the associations between birth defects and increased cancer risk, and expand the range of pediatric disorders included within the Kids First Data Resource. The program accepts proposals for whole genome, exome, and transcriptome sequencing, as well as epigenomic assays of tumor or affected tissue. Applicants are encouraged to propose cohorts of underrepresented racial and ethnic groups or increase representation in existing Kids First Program projects. The data, along with associated clinical and phenotypic data, will be shared with the research community through the Kids First Data Resource Center. For more information and to apply, visit the NIH grants website at http://grants.nih.gov/grants/guide/pa-files/PAR-24-082.html.

Description

As part of the Gabriella Miller Kids First Pediatric Research Program (Kids First Program), the NIH invites applications to submit samples from pediatric cohorts for whole genome sequencing at a Kids First Program-supported sequencing center. Applicants are encouraged to propose sequencing of existing pediatric cancer or structural birth defect cohorts to elucidate the genetic contribution (somatic and/or germline) to childhood cancers, to investigate the genetic etiology of structural birth defects, to study the molecular basis of the associations between birth defects and increased cancer risk, or to expand the range of pediatric disorders included within the Kids First Data Resource. The program will accept applications that propose whole genome, exome, and transcriptome sequencing, as well as epigenomic assays of tumor or affected tissue, when justified. Applicants are encouraged to propose cohorts of underrepresented racial and ethnic groups or to increase racial and ethnic representation of existing Kids First Program projects. These data, and associated clinical and phenotypic data, will become part of the Kids First Data Resource Center for sharing with the research community.

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