Toxic Exposures Clinical Trial Award
ID: 355156Type: Posted
Overview

Buyer

Dept. of the Army -- USAMRAA (DOD-AMRAA)

Eligible Applicants

Unrestricted

Funding Category

Science and Technology and other Research and Development

Funding Instrument

Grant

Opportunity Category

Discretionary

Cost Sharing or Matching Requirement

Yes
Timeline
    Description

    The Department of the Army, through the US Army Medical Research and Development Command (USAMRAA), is offering the Fiscal Year 2024 (FY24) Toxic Exposures Clinical Trial Award (CTA) to support clinical trials focused on military-related toxic exposures. This funding opportunity aims to facilitate research that addresses the prevention, diagnosis, treatment, and underlying mechanisms of health issues stemming from such exposures, with applicants required to align their proposals with at least one FY24 Toxic Exposures Research Program (TERP) Goal and Topic Area. The initiative is crucial for advancing understanding and management of health consequences related to military service, with a total funding pool of $30 million available, including direct costs capped at $1.5 million for single Principal Investigator (PI) projects and $2.5 million for partnering PI applications. Key deadlines include a pre-application due by August 13, 2024, and a full application by November 7, 2024; interested parties can reach out to the CDMRP Help Desk at help@eBRAP.org for further assistance.

    Point(s) of Contact
    Files
    Title
    Posted
    The Department of Defense (DOD) is offering the Fiscal Year 2024 (FY24) Toxic Exposures Clinical Trial Award (CTA) through the Toxic Exposures Research Program (TERP) to support research addressing military-related toxic exposures. This funding opportunity is aimed at clinical trials that will investigate prevention, diagnosis, treatment, and the underlying mechanisms of health issues caused by such exposures. Applicants must align their proposals with at least one FY24 TERP Program Goal and Topic Area, which include elucidating toxic exposure mechanisms and developing therapeutics. Key deadlines include a pre-application by August 13, 2024, and a full application by November 7, 2024. The total funding available is $30 million, with direct costs limited to $1.5 million for single PI projects and $2.5 million for partnering PI applications. Eligible applicants include both extramural and intramural organizations, and the application process involves a two-step submission through the Electronic Biomedical Research Application Portal (eBRAP) and Grants.gov. Proposals emphasizing collaborative efforts with the Department of Veterans Affairs and focusing on military health outcomes are encouraged. The initiative underscores a commitment to understanding and addressing health consequences related to military service exposures.
    Similar Opportunities
    BROAD AGENCY ANNOUNCEMENT (BAA) for Extramural Biomedical and Human Performance Research and Development Department of Defense
    Dept. of the Army -- USAMRAA
    The Department of the Army, through the US Army Medical Research Acquisition Activity (USAMRAA), has announced a Broad Agency Announcement (BAA) for Extramural Biomedical and Human Performance Research and Development. This opportunity invites unrestricted applicants to submit proposals aimed at advancing biomedical research and development, with a focus on enhancing human performance. The program is critical for fostering innovation in science and technology, particularly in areas that support the Department of Defense's mission. The estimated total program funding is $10 million, with individual awards ranging from $750,000 to $50 million, and proposals are due by July 31, 2028. For further inquiries, applicants can contact the CDMRP Help Desk at help@eBRAP.org or by phone at 301-682-5507.
    CCRP Initiative: Chemical Threat Agent-induced Pulmonary and Ocular Pathophysiological Mechanisms (R01 Clinical Trial Not Allowed)
    National Institutes of Health
    The National Institutes of Health (NIH) has announced a Notice of Funding Opportunity (NOFO) titled "CCRP Initiative: Chemical Threat Agent-induced Pulmonary and Ocular Pathophysiological Mechanisms," aimed at supporting research into the mechanisms of chemical toxicity affecting the lungs and eyes. This initiative seeks to fund projects that explore the health impacts of chemical threat agents, with a focus on identifying molecular and genetic targets for therapeutic countermeasures, utilizing various research methodologies such as animal models and computational modeling. A total of approximately $3 million is available to support up to five grants, with each project eligible for a maximum budget of $300,000 per year over a three-year period. Interested applicants should note that the application period opens on August 24, 2024, with a final submission deadline of September 24, 2026, and can direct inquiries to grantsinfo@nih.gov for further information.
    Military and Civilian Partnership for Trauma Readiness Grant Program/Mission Zero
    Admin for Strategic Preparedness and Response
    The Administration for Strategic Preparedness and Response is offering the Military and Civilian Partnership for Trauma Readiness Grant Program, also known as the Mission Zero Act, to support high-acuity trauma centers in enhancing military-civilian partnerships for improved trauma care. This grant program aims to award up to 30 eligible trauma centers, enabling military trauma teams to provide full-time trauma and acute care services, thereby strengthening the nation's response to public health and medical emergencies. With an estimated total program funding of $4 million and an award ceiling of $4 million per grant, interested applicants, including nonprofits without 501(c)(3) status and hospitals, should note that the application period is expected to open on January 15, 2025, with a closing date of April 14, 2025. For further inquiries, applicants can contact Leslie Beck at 301-346-4857 or via email at leslie.beck@hhs.gov.
    NFRP Outreach and Invitation for Response
    Dept. of the Army -- USAMRAA
    The Department of the Army, through the US Army Medical Research Acquisition Activity (USAMRAA), is forecasting an opportunity for a Research-based Other Transactions Agreement (rOTA) under the Neurofibromatosis Research Program (NFRP). This initiative aims to accelerate the clinical translation of basic research related to neurofibromatosis (NF) by conducting collaborative Phase I and II clinical trials focused on promising therapeutic agents for NF1, NF2, and schwannomatosis. Historically, this requirement has been addressed through assistance agreements, and the government is now seeking feedback on this proposed approach, emphasizing the need for cost-sharing arrangements and access to patient populations. Interested parties can direct inquiries to Jason D. Kuhns at jason.d.kuhns.civ@mail.mil, with the opportunity being part of the FY21 portfolio and requiring a demonstrated history of collaborative research among participants.
    Tactical Behaviors for Autonomous Maneuver
    Dept of the Army -- Materiel Command
    The Department of the Army's Materiel Command is offering a funding opportunity through the Tactical Behaviors for Autonomous Maneuver Collaborative Research Program (TBAM-CRP) aimed at enhancing the capabilities of robotic and autonomous systems (RAS) for military operations in complex environments. This program seeks proposals that develop coordinated and adaptive behaviors for small groups of autonomous agents, focusing on innovative maneuver tactics and strategies to operate effectively in multi-domain operations against peer adversaries. The TBAM-CRP is critical for advancing military capabilities, leveraging new technologies in robotics and autonomous systems to improve situational awareness and operational effectiveness on the battlefield. Interested applicants, including institutions of higher education and for-profit organizations, are invited to submit proposals by April 24, 2024, with funding amounts ranging from $100,000 to $2.3 million available per award. For further inquiries, applicants can contact Christopher D. Justice at usarmy.adelphi.devcom-arl.mbx.tbam-crp-questions@army.mil.
    Notice of Intent to Publish a Funding Opportunity Announcement for CCRP Initiative: Countermeasures Against Chemical Threats (CounterACT) Therapeutics Discovery and Early-Stage Development (UG3/UH3 Clinical Trial Not Allowed)
    National Institutes of Health
    The National Institutes of Health (NIH) plans to publish a Notice of Funding Opportunity (NOFO) for the Countermeasures Against Chemical Threats (CounterACT) initiative, focusing on the early-stage development of therapeutics to address health impacts from toxic chemical exposure. This funding opportunity aims to foster collaborations and innovative projects that can effectively mitigate adverse health effects, with an emphasis on the UG3/UH3 activity code for phased development. The NOFO is anticipated to be released in early 2025, with applications due by October 2025, and awards expected to be made by June 2026, marking a significant investment in public health safety. Interested applicants should prepare to align their proposals with the outlined objectives and timelines.
    CCRP Initiative: NIH Countermeasures Against Chemical Threats (CounterACT) Basic Research on Chemical Threats that Affect the Nervous System (R01 Clinical Trial Not Allowed)
    National Institutes of Health
    The National Institutes of Health (NIH) has announced a funding opportunity titled "NIH Countermeasures Against Chemical Threats (CounterACT) Basic Research on Chemical Threats that Affect the Nervous System." This initiative invites applications for basic research projects focused on understanding the mechanisms of toxicity of chemical warfare agents and toxic industrial chemicals that impact the nervous system, with the aim of developing potential therapeutic countermeasures for civilian exposure. The program is particularly significant in enhancing public health responses to chemical threats, emphasizing innovative and transdisciplinary research approaches. Up to four grants totaling $2 million are anticipated for fiscal year 2026, with applications due by 5 PM local time on October 17, 2026. Interested applicants can find more information and contact NIH Grants Information at grantsinfo@nih.gov for inquiries.
    CCRP Initiative: NIH Countermeasures Against Chemical Threats (CounterACT) Basic Research on Chemical Threats that Affect the Nervous System (R01 Clinical Trial Not Allowed)
    National Institutes of Health
    The National Institutes of Health (NIH) is inviting applications for the CCRP Initiative: NIH Countermeasures Against Chemical Threats (CounterACT) program, focusing on basic research related to chemical warfare agents and toxic industrial chemicals that impact the nervous system. The objective is to elucidate mechanisms of toxicity, identify biological markers, and develop potential therapeutic countermeasures for civilian populations exposed to these chemicals. This funding opportunity is critical for enhancing public safety against chemical threats, with a total of $2 million available for up to four awards, each with a maximum annual budget of $300,000 over three years. Interested applicants must submit their proposals by September 17, 2024, and can direct inquiries to grantsinfo@nih.gov for further information.
    Limited Competition: CCRP Initiative: Promoting a Basic Understanding of Chemical Threats to Skin (R34 Clinical Trial Not Allowed)
    National Institutes of Health
    The National Institutes of Health (NIH) is offering a limited competition grant opportunity titled "CCRP Initiative: Promoting a Basic Understanding of Chemical Threats to Skin," aimed at funding fundamental research on skin injuries caused by chemical threats recognized as public health risks. The initiative seeks to enhance understanding of the mechanisms leading to chemical-induced skin injuries and to identify potential therapeutic targets for medical countermeasure development, with a focus on examining two or more Chemicals of Concern, including at least one vesicant. This funding opportunity is crucial for advancing knowledge in the field of chemical threat response and wound healing, with an estimated funding amount of $1.25 million available for fiscal year 2025, allowing for up to five awards capped at $225,000 per year. Applications will open on January 16, 2025, and interested parties can direct inquiries to grantsinfo@nih.gov for further information.
    Fundamental Research to Counter Weapons of Mass Destruction
    Defense Threat Reduction Agency
    The Defense Threat Reduction Agency (DTRA) has announced a Broad Agency Announcement (BAA) for fundamental research aimed at countering Weapons of Mass Destruction (WMD), with funding available from October 1, 2024, to September 30, 2034. This opportunity invites proposals from accredited colleges, universities, and research entities to contribute to DTRA's mission of reducing WMD threats, emphasizing collaboration in areas such as chemical and biological defense. The funding will primarily be awarded as grants, with amounts ranging from $25,000 to $1 million annually, and proposals will undergo a two-phase evaluation process assessing scientific merit and mission relevance. Interested applicants should submit pre-application white papers and can direct inquiries to the BAA Administrative Mailbox at dtra.belvoir.rd.mbx.rd-cb-frbaa25-34-a@mail.mil before the closing date of September 30, 2034.