Single Source for the Continuation of the Human Pancreas Analysis Program (HPAP) for Type 1 Diabetes (HPAP-T1D) (U01 Clinical Trial Not Allowed)

Active
Yes
Status
Posted
Published Date
June 5th, 2024
Close Date
October 24th, 2024
Award Ceiling
$5,500,000.00
Opportunity No.
RFA-DK-25-012

Agency

National Institutes of Health (HHS-NIH11)

Eligible Applicants

Small Businesses

Funding Category

Health

Funding Instrument

Cooperative Agreement

Opportunity Category

Discretionary

Cost Sharing or Matching Requirement

Yes

Summary

The National Institutes of Health (NIH) has posted a grant opportunity titled "Single Source for the Continuation of the Human Pancreas Analysis Program (HPAP) for Type 1 Diabetes (HPAP-T1D) (U01 Clinical Trial Not Allowed)". This funding opportunity falls under the category of Health and is a discretionary grant. The grant is a cooperative agreement and does not require cost sharing or matching. The deadline for applications is October 24, 2024. The purpose of this grant is to provide funding for the continuation of the Human Pancreas Analysis Program for Type 1 Diabetes (HPAP-T1D). The University of Pennsylvania has been identified as the recipient of this single source cooperative agreement. The program aims to identify, collect, and characterize primary pancreatic tissues and immune cells from patients with type 1 diabetes (T1D) or at risk of developing the disease, as well as age-matched controls. The collected data will be analyzed, organized, and shared through the existing PANC DB open-access resource database. The program is part of the Human Islet Research Network (HIRN), which focuses on understanding the loss of human beta cells in T1D and finding strategies to protect and replace functional human beta cell mass. Small businesses and other eligible applicants are invited to apply for this grant opportunity. Non-domestic (non-U.S.) entities and components of U.S. organizations are not eligible to apply. For more information on eligibility, please refer to the full Notice of Funding Opportunity. The maximum award ceiling for this grant is $5,500,000. For further details and to apply, interested parties can visit the following website: http://grants.nih.gov/grants/guide/rfa-files/RFA-DK-25-012.html. If there are any inquiries, please contact NIH Grants Information at grantsinfo@nih.gov.

Description

This Notice of Funding Opportunity (NOFO) is a non-competitive funding opportunity intended to fund a single award. The NIDDK is announcing its intent to issue a single source cooperative agreement to the University of Pennsylvania to continue the mission of the existing Human Pancreas Analysis Program for Type 1 Diabetes (HPAP-T1D). This NOFO will support one team of investigators with combined expertise in human pancreas physiology and pathophysiology; immunology and autoimmunity; collection, processing and multimodal analysis of human pancreatic tissues and immune compartments; and biological database building, curation and management, that will be tasked to: 1) identify, collect and intensively characterize primary pancreatic tissues and immune cells from patients with type 1 diabetes (T1D) or at risk of developing the disease, as well as age-matched controls; and 2) analyze, organize and share the data resulting from the study of these tissues through the existing PANC DB open-access resource database. HPAP-T1D is a component of the Human Islet Research Network or HIRN. HIRN was created in 2014 to support innovative and collaborative translational research to understand how human beta cells are lost in T1D, and to find innovative strategies to protect and replace functional human beta cell mass.

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Opportunity Lifecycle

Title
Type
Grant