The National Institutes of Health (NIH), through the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), announces the funding opportunity titled "NIDDK High Risk Multi-Center Clinical Study Implementation Planning" (PAR-25-090). This initiative aims to support high-risk, investigator-initiated, multi-center clinical studies via a two-part cooperative agreement mechanism (U34), which facilitates early peer review of proposed studies and development of essential operational documents. NIDDK encourages focus on diseases impacting underrepresented populations and emphasizes the importance of community engagement in research planning. Applications must include a Plan for Enhancing Diverse Perspectives (PEDP) and various administrative tasks are to be completed during the U34 phase, laying groundwork for participant recruitment under a subsequent U01 funding opportunity. Key dates include an application opening on May 9, 2025, with a maximum award budget of $225,000 per year for up to two years. Eligible organizations include higher education institutions, nonprofit organizations, and various governmental agencies. The program's structure aims to ensure scientific rigor, operational feasibility, and diversity in research participation, ultimately contributing to improved public health outcomes among diverse communities.