Cooperative AgreementPostedDiscretionary

Limited Competition: Regenerative Medicine Innovation Project (RMIP) Investigator-Initiated Clinical Trials (UH3 Clinical Trial Optional)

National Institutes of Health
RFA-AR-25-014
Application Deadline
Oct 21, 2025
Closed
Days Remaining
0
Deadline passed
Award Ceiling
Total Program Funding

Grant Opportunity Analysis

The National Institutes of Health (NIH) is inviting applications for the Limited Competition: Regenerative Medicine Innovation Project (RMIP) Investigator-Initiated Clinical Trials (UH3 Clinical Trial Optional). This funding opportunity aims to support investigator-initiated clinical trials that advance regenerative medicine, particularly using adult stem cells, as outlined by the 21st Century Cures Act. The initiative is crucial for enhancing research on regenerative therapies and addressing barriers in clinical development, with a total funding amount of up to $3.5 million available, and a maximum of $400,000 in direct costs per year for each awarded project. Interested applicants must submit their proposals by October 21, 2025, and can reach out to NIH Grants Information at grantsinfo@nih.gov for further inquiries or visit the opportunity's webpage for more details.

Eligible Applicants

Others
Additional Eligibility Information

Other Eligible Applicants include the following: Eligible Agencies of the Federal Government; Faith-based or Community-based Organizations; Indian/Native American Tribal Governments (Other than Federally Recognized); Regional Organizations; U.S. Territory or Possession; Non-domestic (non-U.S.) Entities (Foreign Organizations) are not eligible to apply. Non-domestic (non-U.S.) components of U.S. Organizations are not eligible to apply. Foreign components, as defined in the NIH Grants Policy Statement, are allowed.

Grant Documents

2 Files
RFA-AR-25-014-Full-Announcement.html
HTML0 KB6/20/2025
AI Summary
No AI summary available for this file.
RFA-AR-25-014.html
HTML124 KB6/20/2025
AI Summary
The National Institutes of Health (NIH) is soliciting applications for the Limited Competition: Regenerative Medicine Innovation Project (RMIP) under the UH3 Exploratory/Developmental Cooperative Agreement Phase II. This funding opportunity seeks renewal applications from investigator-initiated clinical trials that aim to advance regenerative medicine using adult stem cells, as established by the 21st Century Cures Act. Eligible organizations include various educational institutions, non-profits, and for-profit entities. Notably, applicants are required to match federal funding on a 1:1 basis with non-federal contributions. Key project goals include enhancing research on regenerative therapies and overcoming existing barriers in clinical development. The NIH emphasizes the significance of projects that provide valuable data following previous RMIP trials. The expected funding totals up to $3.5 million, with a maximum of $400,000 in direct costs per year per awarded project, and the application period runs through October 22, 2025. NIH grants policies apply, including strict adherence to application guidelines and requirements for sharing data generated from the projects. Applications will be evaluated based on scientific merit, approach, and investigator qualifications, ensuring a focused enhancement of regenerative medicine's impact on health.

Related Grant Opportunities

Project Timeline

postedOriginal Opportunity PostedJun 17, 2025
deadlineApplication DeadlineOct 21, 2025
expiryArchive DateNov 26, 2025

Funding Details

No cost sharing required

Agency & Classification

Agency
National Institutes of Health(HHS-NIH11)
Funding Category
Health
Funding Instrument
Cooperative Agreement

Grantor Contact

CFDA Numbers

93.867

Official Sources