The Agriculture and Food Research Initiative (AFRI) Sustainable Agricultural Systems (SAS) Request for Applications (RFA) for Fiscal Year 2025 aims to foster innovative agricultural projects. With an anticipated funding of $70 million, grants range from $2.5 million to $10 million. The application deadline is May 15, 2025, with an optional Notification of Intent due by March 27, 2025. The initiative focuses on transdisciplinary approaches to enhance climate-smart, sustainable, and accessible food systems, while addressing challenges such as climate change, food security, and rural prosperity. Projects must integrate research, education, and extension components, emphasizing stakeholder engagement and equitable benefits for underserved communities. The funding encourages proposals that align with three long-term goals: strengthening the bioeconomy, increasing food and nutrition security, and promoting climate-smart agriculture and forestry. The RFA also highlights the importance of diversity, equity, inclusion, and accessibility in applications, with a call for innovative educational methods to build a skilled workforce. Collaboration with various sectors, including international partners, is encouraged to enhance the impact of sustainable agricultural practices.