The Department of the Army, through the US Army Medical Research and Development Command (USAMRAA), is offering the FY25 Peer Reviewed Cancer Research Program (PRCRP) Impact Award to support high-impact research aimed at improving clinical cancer care relevant to military health. This grant seeks mature research projects that demonstrate potential for near-term benefits in cancer treatment and patient outcomes, particularly focusing on specific cancer types such as bladder, blood, and brain cancers, while excluding melanoma and breast cancers. The program emphasizes the importance of preliminary data, collaboration with Department of Defense (DOD) and Veterans Affairs (VA) entities, and rigorous study designs to advance cancer detection and treatment for service members and their families. The estimated total program funding is $45.5 million, with individual awards capped at $1.4 million for single Principal Investigator applications and $1.75 million for partnering applications, over a maximum period of three years. Interested applicants must submit a pre-application by September 25, 2025, and can contact the CDMRP Help Desk at help@eBRAP.org for further assistance.