The National Institutes of Health (NIH) is inviting applications for the Specialized Programs of Research Excellence (SPOREs) in Human Cancers, aimed at funding innovative P50 Research Center Grants for the years 2024, 2025, and 2026. This initiative focuses on supporting translational research that enhances prevention, early detection, diagnosis, and treatment of organ-specific cancers or closely related groups, with a requirement for clinical trials. The SPORE program is crucial for advancing cancer research and improving treatment outcomes, emphasizing collaboration, research infrastructure, and addressing health disparities. Interested applicants can apply starting December 25, 2023, with a maximum funding of $1.4 million in direct costs annually, and must submit their proposals by the specified deadlines in January, May, September, and January 2026. For further inquiries, applicants can contact NIH Grants Information at grantsinfo@nih.gov or visit the additional information link at https://grants.nih.gov/grants/guide/pa-files/PAR-23-284.html.