The National Institutes of Health (NIH) is inviting applications for the Silvio O. Conte Digestive Diseases Research Core Centers (DDRCCs) under the funding opportunity RFA-DK-25-003. This initiative aims to enhance collaboration among basic and clinical researchers focused on digestive and liver diseases by providing shared resources that foster productivity and innovation, with each center organized around a central theme aligned with the mission of the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK). Applicants must demonstrate a robust research base with a minimum of $3 million in direct costs per year from federally funded projects, including a mandatory Plan for Enhancing Diverse Perspectives (PEDP) and a strong administrative structure. Approximately $4.8 million is available for four new awards each year, with a maximum budget of $750,000 in direct costs per year over a five-year period. The application submission cycle opens on January 22, 2024, with reviews commencing shortly thereafter. For further inquiries, applicants can contact NIH Grants Information at grantsinfo@nih.gov.