The Defense Advanced Research Projects Agency (DARPA) is inviting innovative proposals for the Hermes program, which focuses on developing systemic drug delivery platforms for medical countermeasures (MCMs). The program seeks transformative approaches that ensure effective biodistribution, high endosomal escape efficiency, and low toxicity in the proposed delivery systems. Successful applicants will need to provide a comprehensive proposal detailing their delivery platform, including a screening pipeline, monitoring systems for biodistribution and expression, immunogenicity/toxicity assessment methods, and justification for the chosen therapeutic cargo. Proposals are due by June 11, 2024, at 4:00 PM ET, and interested parties can reach out to Dr. Shannon Greene at HermesBAA@darpa.mil for further inquiries. More information can be found on the SAM.gov Contract Opportunities website.