The National Institutes of Health (NIH) is offering a funding opportunity for investigator-initiated research in computational genomics and data science through the R21 grant mechanism, specifically excluding clinical trials. This grant aims to enhance fundamental genomics research by supporting innovative analytical methodologies and tools that are applicable to human health and disease, with a focus on scalable management of complex genomic datasets. The funding is particularly important for advancing computational approaches, data integration, visualization, and secure data sharing, which are critical for the biomedical research community. Eligible applicants include a wide range of entities such as academic institutions, nonprofits, and government organizations, with project budgets capped at $275,000 over two years. Interested parties should contact the NIH OER Webmaster at grantsinfo@nih.gov for assistance and must submit their applications by January 7, 2025.