The USAID Sustaining Epidemic Control through Unified Prevention (SECURE) Activity is a federal grant opportunity posted by the South Africa USAID-Pretoria. This cooperative agreement falls under the category of Health and has a funding amount ranging from $14,000,000 to $35,000,000. The grant aims to reach the general population and key populations (KP) with person-centered, evidence-based biomedical HIV prevention, testing, and treatment services. It supports the Government of Lesotho's efforts to revitalize HIV/AIDS prevention at the community level and aligns with the UNAIDS' HIV Prevention 2025 Roadmap. The SECURE Activity contributes to the UNAIDS 95-95-95 fast-track targets and the UNAIDS 10-10-10 targets. Eligible applicants for this grant are unrestricted and include U.S. private voluntary organizations, non-governmental organizations, non-profit organizations, universities, research organizations, professional associations, and relevant special interest associations. Public International Organizations (PIOs) and faith-based and community organizations are also eligible. The closing date for applications is March 15, 2024. For more information, contact Nya Kwai Boayue, the Agreement Officer, at nboayue@usaid.gov.