The United States Agency for International Development (USAID) is inviting applications for a cooperative agreement under the Child Protection Activity program in Ghana, aiming to enhance child protection, development, and care systems over five years with a budget of approximately $9.99 million. The initiative targets vulnerable children and their families, particularly focusing on marginalized groups including children with disabilities, those at risk of trafficking, adolescent girls facing early marriages, and children living outside family care. The program is designed to address root causes of child welfare issues such as poverty and violence, by promoting evidence-based, community-centered interventions that strengthen family and community resilience. Eligible entities can include non-profits, NGOs, and private organizations, with a required cost-sharing of at least 10%. Proposals should align with USAID’s strategic objectives, incorporating gender and disability considerations, and demonstrating collaboration with local stakeholders. Applications will be evaluated based on merit, and interested parties are urged to consult the full Notice of Funding Opportunity (NOFO) for submission requirements and guidelines. Overall, this initiative aligns with broader U.S. foreign assistance efforts to ensure safe, nurturing environments for children in Ghana, while supporting local development partners in implementing the proposed interventions.