The Department of Energy's Office of Science is offering a funding opportunity through the EXPRESS: 2025 Exploratory Research for Extreme-Scale Science program, aimed at advancing scientific computing and exploring innovative research approaches. This initiative will provide approximately $16 million to support 20 awards, with individual grants ranging from $200,000 to $1,000,000 over a two-year period, focusing on fundamental research topics such as quantum computing, neuromorphic computing, and AI model understanding. Eligible applicants include DOE/NNSA National Laboratories, federally funded research centers, and U.S. academic institutions, with a pre-application deadline of February 25, 2025, and full applications due by May 6, 2025. For further information, interested parties can contact Hal J. Finkel at hal.finkel@science.doe.gov or visit the program's website at https://science.osti.gov/ascr.