Biological Technologies
ID: HR001126S0003Type: Solicitation
Overview

Buyer

DEPT OF DEFENSEDEFENSE ADVANCED RESEARCH PROJECTS AGENCY (DARPA)DEF ADVANCED RESEARCH PROJECTS AGCYARLINGTON, VA, 222032114, USA

NAICS

Research and Development in Biotechnology (except Nanobiotechnology) (541714)

PSC

NATIONAL DEFENSE R&D SERVICES; DEPARTMENT OF DEFENSE - MILITARY; BASIC RESEARCH (AC11)
Timeline
    Description

    The Defense Advanced Research Projects Agency (DARPA) is soliciting proposals for its Biological Technologies Office (BTO) under Broad Agency Announcement HR001126S0003, aimed at leveraging biological properties and processes to enhance the protection of U.S. warfighters. The BAA invites innovative research proposals that focus on various areas, including biological and chemical technologies for national security, AI/ML applications, combat casualty care, and environmental solutions, with a clear exclusion of evolutionary improvements to existing practices. Proposals will be evaluated based on scientific merit, relevance to DARPA's mission, and cost realism, with multiple award types anticipated, including contracts and cooperative agreements, and an accelerated award option available for proposals under $2 million. Interested parties should submit abstracts and proposals on a rolling basis until September 30, 2026, and can contact the BAA Coordinator at BTOBAA2026@darpa.mil for further information.

    Point(s) of Contact
    BAA Coordinator
    BTOBAA2026@darpa.mil
    Files
    Title
    Posted
    The HR00112560003 Proposal Abstract outlines mandatory instructions for submitting abstracts for the Biological Technologies Broad Agency Announcement (BAA). Proposers must use a specific template, adhere to formatting guidelines (8-1/2 x 11-inch paper, 1-inch margins, 12-point font, max 2 pages), and submit in PDF or Word. Abstracts should be UNCLASSIFIED/CUI and properly mark proprietary data. Submitting an abstract and receiving an invitation are prerequisites for full proposal submission; uninvited proposals will not be reviewed. The abstract requires a cover sheet with contact details and estimated costs, and sections covering Goals and Impact, Technical Approach, Capabilities/Management Plan, and a Bibliography. DARPA will notify proposers via email regarding invitations to submit full proposals, emphasizing that an invitation does not guarantee an award.
    Attachment B: HR001126S0003 outlines the mandatory template for Volume I, Technical and Management Proposals, for the Biological Technologies Broad Agency Announcement (BAA). This document is crucial for federal government RFPs, federal grants, and state/local RFPs. It details submission requirements, including page limits, formatting, and content for various sections such as the Proposal Summary, Technical Plan, Statement of Work, and Management Plan. Proposers must use specific attachments based on the requested award type (Procurement Contract, Other Transaction, or Cooperative Agreement) and complete the DARPA Cost Proposal Spreadsheet. The document emphasizes conciseness, specific examples, and adherence to submission deadlines. It also includes sections for Organizational Conflict of Interest disclosures, intellectual property assertions, and representations and certifications, ensuring compliance and transparency in the proposal process.
    Attachment C and E, titled "HR001125S0015 Volume II: Cost Volume Template" and "HR001126S0003 Volume 2: Cost Volume Template" respectively, outlines the comprehensive requirements for submitting cost proposals for federal government RFPs, specifically for procurement contracts, cooperative agreements, or Other Transactions. Proposers must use Attachment D (DARPA Cost Proposal Spreadsheet) for detailed cost breakdowns, ensuring traceability between the prime organization, subcontractors, and the Statement of Work (SOW). The cost volume has no page limit but must focus solely on cost-related information, addressing the full program (base + options). It requires a cover sheet with organizational and contact details, requested award instrument, performance periods, and total proposed costs by fiscal year. Detailed cost breakdowns are required for direct labor, indirect costs, materials, equipment, travel, other direct costs, cost sharing, consultant costs, and subawardee costs. Specific requirements are outlined for procurement contracts (certified cost or pricing data, small business subcontracting plan, approved cost accounting system documentation) and Other Transactions for Prototypes (nontraditional defense contractor status, cost share, and detailed milestones). All submissions must adhere to formatting guidelines and be in English.
    The DARPA Streamlined Cost Proposal Spreadsheet is a comprehensive template for federal government RFPs, grants, and state/local RFPs. It standardizes cost breakdowns across various categories, including direct labor, fringe, overhead, subcontracts, consultants, and other direct costs (materials, equipment, travel, ODCs). The spreadsheet requires detailed documentation for each cost element, emphasizing traceable formulas and supporting documentation like vendor quotes or historical pricing. It includes specific instructions for prime contractors and subcontractors, guidance on indirect rates (Fringe, Overhead, G&A/F&A), and a section for outlining project milestones and associated payments, particularly for Other Transaction (OT) Awards. The document stresses the importance of accuracy, adherence to federal cost principles, and alignment with technical proposals, providing a structured approach for transparent and justifiable cost submissions.
    This document outlines the classified submission instructions for Broad Agency Announcement HR001126S0003, focusing on proposals containing classified information (Confidential, Secret, Top Secret, Sensitive Compartmented Information, and Special Access Program). Proposers must not use DARPA's BAA Website or Grants.gov for classified submissions. Key requirements include possessing approved facilities, information systems, and appropriately cleared personnel, adhering to DoD Manual 8570.01-M for IA/Cybersecurity duties, and obtaining permission for classified information from other sources. Submissions require three hard copies and two CD-ROMs in PDF format, clearly labeled. Specific handling and transmission guidance is provided for each classification level, including hand-carrying by authorized couriers for Top Secret and coordination with DARPA’s Classified Document Registry. Proposals with both classified and unclassified portions should separate them, submitting the unclassified part via the BAA Website and the classified part separately, with an unclassified email notification. Special Access Program information has additional requirements concerning facility accreditations, IT systems, and CIO approval for non-enterprise SAP IT systems.
    The Controlled Unclassified Information Guide, created by the DARPA Biological Technologies Office (BTO), establishes guidelines for handling, marking, and protecting unclassified yet sensitive information within various BTO programs. This guide ensures uniformity in CUI management, drawing from DoD directives and DARPA security policies. It outlines procedures for identifying, safeguarding, and disseminating CUI, and addresses challenges such as improper classification and unauthorized disclosure. The document specifies various CUI categories, including Controlled Technical Information, Export Control, Financial, Operational Security, and Privacy, detailing their protection requirements and exemptions under the Freedom of Information Act. The guide emphasizes immediate reporting of unauthorized disclosures and provides charts to assist in CUI identification and appropriate marking to control dissemination.
    The DARPA Accelerated Award Option allows proposers to expedite contract or Other Transaction (OT) agreement awards for efforts not exceeding $2,000,000. By agreeing to prescribed terms and conditions in advance, proposers can receive awards within 30 days of selection notification. To qualify, proposals must meet specific stipulations, including unclassified effort, specific data rights, and inclusion of a DARPA Cost Proposal Spreadsheet. Additional requirements apply to Procurement Contracts, OT for Prototypes, and OT for Research awards, such as DCAA-reviewed accounting systems, agreement to FAR/DFARS clauses, and specific model OT agreement terms. Subawardees must also adhere to these stipulations. Failure to honor these conditions will result in the revocation of DARPA's commitment to an accelerated award.
    This government contract document, HR00112XCXXXX, outlines the terms and conditions for a Cost-Plus-Fixed-Fee (CPFF) completion contract with the Defense Advanced Research Projects Agency (DARPA). It details the supplies and services required, which include accomplishing tasks defined in the Statement of Work (SOW) and delivering technical data and reports. The contract specifies inspection and acceptance at the destination by the Government for all items. It mandates electronic invoicing through the Wide Area WorkFlow (WAWF) system and provides detailed instructions for payment requests and receiving reports. The document also incorporates numerous Federal Acquisition Regulation (FAR) and Defense Federal Acquisition Regulation Supplement (DFARS) clauses covering areas such as safeguarding contractor information systems, overtime premiums, equal opportunity for veterans and individuals with disabilities, subcontracting requirements, and public release of information. Key attachments include the Statement of Work, Additional Requirements, and Data Rights Assertions List.
    This government contract (HR00112XCXXXX) is a Cost-Plus-Fixed-Fee (CPFF) completion contract for research and development tasks, including technical data and contractor-acquired property. The contract outlines detailed clauses for inspection, acceptance, deliveries, and payment instructions via the Wide Area WorkFlow (WAWF) system. It incorporates numerous Federal Acquisition Regulation (FAR) and Defense Federal Acquisition Regulation Supplement (DFARS) clauses covering areas such as safeguarding contractor information systems, equal opportunity for veterans and individuals with disabilities, subcontracts, and intellectual property rights. Key deliverables include monthly R&D status reports, financial status reports, and a final report. The contract emphasizes adherence to specific reporting instructions and outlines restrictions on public release of information, requiring prior approval from DARPA.
    The document outlines additional circumstance-driven clauses for federal government contracts, supplementing baseline model contracts for large and small businesses. These clauses are categorized by dollar thresholds and specific contract types, indicating cumulative requirements for higher-value awards. For contracts exceeding $2 million, clauses address limitations on pass-through charges, price reductions for defective cost data, subcontractor cost data, pension adjustments, post-retirement benefits, ownership changes, and cost accounting standards. Contracts over $5 million include a post-award disclosure requirement for employees working in the People's Republic of China. Awards exceeding $6 million mandate clauses for business ethics, market research, agency inspector general oversight, and hotline poster display. Contracts over $15 million require reporting intended performance outside the U.S. and Canada. Specific clauses are also detailed for contracts containing options, those involving access to classified information, and those with educational institutions, covering aspects like contract extensions, security requirements, patent applications, drug-free workforce, telecommunications security, military recruitment, and termination for convenience.
    This DARPA agreement outlines the general terms and conditions for research and development projects, specifically for the creation of prototypes under 10 U.S.C. § 4022. It details the agreement structure, including clauses on intellectual property (patent and data rights), project management, payment milestones, and dispute resolution. Key aspects include the Performer's responsibility for technical execution, DARPA's continuous involvement, and the requirement for public release approval. The document also addresses critical compliance areas like safeguarding covered defense information, cyber incident reporting, and prohibitions on certain telecommunications equipment from covered foreign countries. It emphasizes the importance of Nontraditional Defense Contractor (NDC) participation, outlining specific requirements for partners and their contributions. Attachments provide further details on task descriptions, payment schedules, and invoicing procedures via Wide Area Workflow (WAWF), ensuring a structured approach to federal research agreements.
    This document outlines an Other Transaction (OT) Agreement for research between DARPA and a performer, detailing the general terms and conditions for federal grants. It covers the scope, term, project management, obligation and payment schedules based on milestones, and dispute resolution procedures. Key articles address patent and data rights, foreign access to technology, property ownership and disposition, safeguarding covered defense information and cyber incident reporting, civil rights compliance, public release of information, and prohibitions on certain telecommunications equipment. The agreement emphasizes the performer's responsibility for technical management and compliance with reporting requirements through the DARPA VAULT system. It also includes instructions for invoicing via Wide Area Work Flow (WAWF) and defines critical terms, ensuring adherence to national security and federal regulations throughout the research and development program.
    This government file outlines the terms and conditions for a Cooperative Agreement issued by the Defense Advanced Research Projects Agency (DARPA). The agreement, identified as HR0011XX2XXXX, funds research supporting a DARPA program and involves substantial government involvement in managing the project. Key aspects include a two-phase performance period, a total base and unexercised option amount of $XXX,XXX (plus potential cost-share), and specific reporting requirements like Annual/Final Research Performance Progress Reports and Financial Status Reports. It details payment procedures via electronic funds transfer and mandates compliance with various federal regulations and DARPA-specific addendums, including provisions for intellectual property, security, human subject protection, and animal welfare. The document also includes certifications regarding debarment, drug-free workplace, lobbying, and tax liability, ensuring adherence to federal standards.
    DARPA's Biological Technologies Office (BTO) issued Broad Agency Announcement HR0011226S0003, soliciting proposals for biological and chemical technologies to enhance warfighter protection and national security. The BAA, effective October 1, 2025, seeks transformative solutions, excluding incremental improvements. Key focus areas include AI/ML applications in biological data, combat casualty care, human performance optimization, novel materials/sensors, agricultural/environmental solutions, and biodefense/biosecurity. Abstracts and proposals are accepted on a rolling basis until September 30, 2026. Submitting an abstract and receiving an invitation are mandatory before proposal submission. Evaluation criteria prioritize scientific/technical merit, relevance to DARPA's mission, and cost/schedule realism. Multiple award types are anticipated, including Procurement Contracts, Cooperative Agreements, and Other Transaction Agreements. Specific instructions and templates are provided for submission, including an accelerated award option for proposals under $2,000,000. Non-U.S. entities and various business types are encouraged to apply, with specific exclusions for FFRDCs, UARCs, and Government Entities. Proposals involving human subjects or animal use must comply with DARPA's approval procedures.
    Lifecycle
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    Biological Technologies
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