The Department of Health and Human Services, specifically the National Institutes of Health (NIH), intends to negotiate a sole-source contract with Vitrium Systems Inc. for an annual subscription to their software license for Vitrium, a Digital Rights Management (DRM) solution. This procurement aims to secure a software license that supports encryption and access control for proposal documents submitted to the electronic Review Support Site (eRSS), as the current software, FileOpen, is incompatible with the NIH's technology upgrade to .NET 6. The Vitrium software is essential for protecting confidential content and intellectual property, offering superior document access tracking and eliminating the need for client plugin installations. Interested vendors may submit capability statements by email to Rubyanne Matthews by 11:00 AM EST on March 21, 2025, referencing NOI-NIAID-25-2257446, as this is a firm-fixed price contract with only one award anticipated.