PREVENT Cancer Preclinical Drug Development Program
ID: HHS-NIH-NCI-TSB-0405Type: Justification
Overview

Buyer

HEALTH AND HUMAN SERVICES, DEPARTMENT OFNATIONAL INSTITUTES OF HEALTHNIH NCIBethesda, MD, 20892, USA

PSC

HEALTH R&D SERVICES; HEALTH CARE SERVICES; APPLIED RESEARCH (AN12)

Original Source

https://sam.gov/opp/c49afa46f23b42fb91c31435bce321f3/view
Timeline
    Description

    The Department of Health and Human Services, specifically the National Institutes of Health (NIH), is seeking to increase the programmatic ceiling for several contracts under the PREVENT Cancer Preclinical Drug Development Program. This initiative aims to enhance funding for ongoing contracts numbered 75N91019D00012 through 75N91019D00026, which are focused on health research and development services critical to advancing cancer treatment options. The adjustments to the contract values are essential for supporting continued research efforts in the field of cancer prevention and treatment. For further inquiries, interested parties can contact Rachel Turk at rachel.turk@nih.gov.

    Point(s) of Contact
    Rachel Turk
    rachel.turk@nih.gov
    Files
    Title
    Posted
    Attachment 1 - Statements of Work.pdf
    The IDIQ Statement of Work outlines the PREVENT Cancer Preclinical Drug Development Program's scope, which encompasses the development of potential cancer preventive agents through extensive preclinical efficacy testing and biomarker evaluation, including toxicology studies and cGMP production of vaccines. Specific tasks include conducting preclinical animal studies, establishing quality management protocols, and ensuring compliance with federal regulations while addressing various types of agents such as chemopreventive and immunopreventive products. Furthermore, contractors must provide comprehensive project management and documentation, highlighting the importance of collaboration, oversight, and adherence to Good Laboratory Practice (GLP) and cGMP standards to facilitate regulatory submissions for clinical trials.
    Attachment 3 - SAM.gov Pre-solicitation Notice.pdf
    The National Cancer Institute (NCI) has issued a sole-source notice for modifications to increase funding ceilings on existing PREVENT Cancer Preclinical Drug Development Program contracts, allowing for advanced research in cancer preventive interventions. The modifications will raise the ceiling from approximately $50 million to nearly $75 million, facilitating continued Efficacy, Toxicology/Pharmacology, and cGMP work through a non-competitive process among the fourteen current contractors. Interested parties, particularly small businesses, are invited to submit capability statements by October 28, 2022, to be considered for potential future procurement opportunities.
    JA Redacted Final.pdf
    The document outlines a request for a $25 million increase to the programmatic ceiling of the PREVENT Cancer Preclinical Drug Development Program's IDIQ contracts, raising the total to $74.9 million, to ensure continuity in critical cancer research amid rising costs and successful program expansions. The program's effectiveness has led to increased demand for advanced preclinical development, necessitating this funding adjustment prior to a planned re-competition for contracts in November 2023. All task orders will continue to be competitively solicited among the fourteen existing contractors to maintain the program’s momentum and scientific integrity.
    Lifecycle
    Title
    Type
    PREVENT Cancer Preclinical Drug Development Program
    Currently viewing
    Justification
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