PREVENT Cancer Preclinical Drug Development Program
ID: HHS-NIH-NCI-TSB-0405Type: Justification
AwardedMar 28, 2023
Award #:Attached
Overview

Buyer

HEALTH AND HUMAN SERVICES, DEPARTMENT OFNATIONAL INSTITUTES OF HEALTHNIH NCIBethesda, MD, 20892, USA

PSC

HEALTH R&D SERVICES; HEALTH CARE SERVICES; APPLIED RESEARCH (AN12)

Original Source

https://sam.gov/opp/c49afa46f23b42fb91c31435bce321f3/view
Timeline
    Description

    The Department of Health and Human Services, specifically the National Institutes of Health (NIH), is seeking to increase the programmatic ceiling for several contracts under the PREVENT Cancer Preclinical Drug Development Program. This initiative aims to enhance funding for ongoing contracts numbered 75N91019D00012 through 75N91019D00026, which are focused on health research and development services critical to advancing cancer treatment options. The adjustments to the contract values are essential for supporting continued research efforts in the field of cancer prevention and treatment. For further inquiries, interested parties can contact Rachel Turk at rachel.turk@nih.gov.

    Point(s) of Contact
    Rachel Turk
    rachel.turk@nih.gov
    Files
    Title
    Posted
    Attachment 1 - Statements of Work.pdf
    The IDIQ Statement of Work outlines the PREVENT Cancer Preclinical Drug Development Program's scope, which encompasses the development of potential cancer preventive agents through extensive preclinical efficacy testing and biomarker evaluation, including toxicology studies and cGMP production of vaccines. Specific tasks include conducting preclinical animal studies, establishing quality management protocols, and ensuring compliance with federal regulations while addressing various types of agents such as chemopreventive and immunopreventive products. Furthermore, contractors must provide comprehensive project management and documentation, highlighting the importance of collaboration, oversight, and adherence to Good Laboratory Practice (GLP) and cGMP standards to facilitate regulatory submissions for clinical trials.
    Attachment 3 - SAM.gov Pre-solicitation Notice.pdf
    The National Cancer Institute (NCI) has issued a sole-source notice for modifications to increase funding ceilings on existing PREVENT Cancer Preclinical Drug Development Program contracts, allowing for advanced research in cancer preventive interventions. The modifications will raise the ceiling from approximately $50 million to nearly $75 million, facilitating continued Efficacy, Toxicology/Pharmacology, and cGMP work through a non-competitive process among the fourteen current contractors. Interested parties, particularly small businesses, are invited to submit capability statements by October 28, 2022, to be considered for potential future procurement opportunities.
    JA Redacted Final.pdf
    The document outlines a request for a $25 million increase to the programmatic ceiling of the PREVENT Cancer Preclinical Drug Development Program's IDIQ contracts, raising the total to $74.9 million, to ensure continuity in critical cancer research amid rising costs and successful program expansions. The program's effectiveness has led to increased demand for advanced preclinical development, necessitating this funding adjustment prior to a planned re-competition for contracts in November 2023. All task orders will continue to be competitively solicited among the fourteen existing contractors to maintain the program’s momentum and scientific integrity.
    Similar Opportunities
    NCI OA Special Notice of Subcontract Opportunity at the Frederick National Laboratory for Cancer Research
    Health And Human Services, Department Of
    The Department of Health and Human Services, specifically the National Institutes of Health (NIH), has issued a Special Notice regarding subcontracting opportunities at the Frederick National Laboratory for Cancer Research (FNLCR). This opportunity focuses on the need for laboratory assays and services to assess cytokines in nasal mucosa samples for up to nine phase 1 trials and two phase 2 trials related to the NextGen COVID-19 vaccine program, which is critical for advancing the National Institute of Allergy and Infectious Diseases (NIAID) mission. The FNLCR, operated by Leidos Biomedical Research, Inc., plays a vital role in cancer and AIDS research, and this notice aims to inform potential subcontractors of the requirements without constituting a formal solicitation. Interested parties can reach out to Tara Phillips at tara.phillips@nih.gov for further details regarding Solicitation/RFP No. S26-111, with a response date set for January 14, 2026.
    NOTICE OF INTENT TO AWARD A SOLE SOURCE MODIFICATION UNDER CONTRACT NO. 75N95022D00017 WITH THE EMMES COMPANY, LLC.
    Health And Human Services, Department Of
    The Department of Health and Human Services, specifically the National Institutes of Health (NIH), intends to award a sole source modification under Contract No. 75N95022D00017 to The Emmes Company, LLC, increasing the contract value by $13,158,436 to a total of $44,313,082. This modification aims to ensure the continuation of critical support services for ongoing and upcoming clinical trials related to substance use disorders, particularly in response to the national opioid crisis. The contract encompasses a range of services, including the establishment of secure data management systems, clinical trial design and analysis, and quality monitoring of study data. Interested parties may submit capability statements or objections to the proposed modification by December 30, 2025, to the primary contact, Llakim Dubroff, at llakim.dubroff@nih.gov.
    Biospecimen Core Resource
    Health And Human Services, Department Of
    The Department of Health and Human Services, specifically the National Institutes of Health (NIH) under the National Cancer Institute (NCI), is seeking to establish a Biospecimen Core Resource (BCR) to support various biospecimen-related activities. The BCR will operate under documented Standard Operating Procedures (SOPs) to facilitate the collection, processing, distribution, and storage of biospecimens as outlined in NCI Task Orders. This initiative is crucial for advancing cancer research and ensuring the integrity and availability of biospecimens for scientific studies. Interested parties can reach out to Apisit Viriya at apisit.viriya@nih.gov or Mataya Robinson at mataya.robinson@nih.gov for further details regarding this opportunity.
    GraphPad Prism Subscription Renewal
    Health And Human Services, Department Of
    The Department of Health and Human Services, specifically the National Institutes of Health (NIH), is seeking to renew a contract for 500 subscriptions of GraphPad Prism software, which is critical for biostatistical analysis and scientific graphing. This non-competitive procurement is justified under the Federal Acquisition Regulation (FAR) due to GraphPad Software, LLC being the sole provider of the software, with the renewal period set from April 8, 2025, to April 7, 2026. GraphPad Prism is widely utilized by research institutions and pharmaceutical companies, ensuring the accuracy and efficiency of scientific data analysis within the NIH. Interested vendors may express their capabilities, but the government retains discretion over competitive offers, with the total contract value not exceeding $250,000. For inquiries, contact Verne L. Griffin at verne.griffin@nih.gov or 301-594-7730, or Michael L. Falzone at michael.falzone@nih.gov or 301-827-1873.
    Parking for the National Cancer Institute (NCI) Shady Grove Campus
    Health And Human Services, Department Of
    The Department of Health and Human Services, through the National Institutes of Health (NIH) and the National Cancer Institute (NCI), is seeking to procure parking garage services for its Shady Grove Campus in Maryland. The contract will provide parking for 1,963 vehicles and 10 motorcycles, exclusively for NCI employees and visitors, ensuring adequate access to the facility. This service is crucial for maintaining operational efficiency and accessibility at the NCI, which plays a vital role in cancer research and treatment. Interested vendors can reach out to Michelle Nguyen at michelle.nguyen2@nih.gov or Linda Park at linda.park@nih.gov for further details regarding this opportunity.
    Data Access Program
    Health And Human Services, Department Of
    The Department of Health and Human Services, specifically the National Institutes of Health (NIH), is seeking qualified contractors for the Data Access Program, aimed at enhancing access to linked datasets for research on aging. The primary objectives include reviewing requests for CMS-linked datasets, conducting data linkage, maintaining data documentation, and providing technical assistance to researchers, all while ensuring compliance with security standards. This initiative is crucial for facilitating high-quality research on health care utilization and outcomes among older adults. Interested parties can contact Shaun Rostad at shaun.rostad@nih.gov or Linda Smith at linda.smith2@nih.gov for further information. The Request for Proposals (RFP No. 75N95023R00003) is expected to be released on or about January 26, 2026, with proposals due 45 days after the release date.
    R--RADx Award Management
    Health And Human Services, Department Of
    The Department of Health and Human Services, specifically the National Institutes of Health (NIH), is seeking sources for the RADx Award Management through a Special Notice. This procurement aims to identify qualified entities that can provide management consulting services related to the RADx initiative, which is crucial for enhancing COVID-19 testing capabilities and supporting public health efforts. Interested parties are encouraged to reach out to Melanie D. Suarez at melanie.suarez@nih.gov or call +1 301 827 7558 for further information regarding this opportunity. The notice emphasizes the importance of professional program management and support services in achieving the objectives of the RADx program.
    Administrative Support for Chernobyl Projects in Ukraine
    Health And Human Services, Department Of
    The Department of Health and Human Services, specifically the National Institutes of Health (NIH), is seeking administrative support for ongoing Chernobyl health effects studies in Ukraine. The contract, identified as 75N91020C00008, aims to continue collaboration with Ukrainian research institutes through the Science and Technology Center in Ukraine (STCU), which has been identified as the sole-source contractor due to its unique qualifications and extensive experience in the region. This support is crucial for the successful management of projects such as the "Clinical Cohort of Ukrainian Cleanup Workers" and the "Ukrainian Thyroid Cohort/Breast Cancer Project," with the contract set to extend until March 31, 2024. Interested parties can reach out to Kari Peterson at kari.peterson@nih.gov or by phone at 240-276-7480 for further information.
    Housing Agreement for NIH Patients
    Health And Human Services, Department Of
    The Department of Health and Human Services, specifically the National Institutes of Health (NIH), is seeking proposals for a Housing Agreement for NIH Patients. This procurement aims to establish housing arrangements for patients receiving care at NIH facilities, ensuring they have access to suitable accommodations during their treatment. The services are critical for supporting patient care and enhancing the overall experience for individuals undergoing medical procedures at NIH. Interested parties can reach out to Roxane Burkett at burkettr@nhlbi.nih.gov or by phone at +1 301 435 6671 for further details regarding the solicitation process.
    AN41--Research Core Facility Access to High-Throughput Genomics and Cancer Bioinformatics Pre-solicitation Notice with Intent to Sole Source
    Veterans Affairs, Department Of
    The Department of Veterans Affairs (VA) intends to award a sole source contract to the University of Utah, Huntsman Cancer Institute (HCI), for specialized research services in high-throughput genomics and cancer bioinformatics. This five-year contract, valued at approximately $4,000,000, will support ongoing research programs at the Salt Lake City VA Medical Center, leveraging HCI's unique expertise and established relationship with the VA. The services provided are critical for advancing cancer research and treatment, and due to the specific requirements and ongoing projects, HCI is deemed the only capable provider. Interested parties may contact Contracting Officer Ann Marie Stewart at annmarie.stewart@va.gov by December 30, 2025, to express interest, although the decision for a competitive procurement remains at the discretion of the Contracting Officer.