The Department of Health and Human Services, specifically the National Institutes of Health (NIH), intends to award a sole source modification under Contract No. 75N95022D00017 to The Emmes Company, LLC, increasing the contract value by $13,158,436 to a total of $44,313,082. This modification aims to ensure the continuation of critical support services for ongoing and upcoming clinical trials related to substance use disorders, particularly in response to the national opioid crisis. The contract encompasses a range of services, including the establishment of secure data management systems, clinical trial design and analysis, and quality monitoring of study data. Interested parties may submit capability statements or objections to the proposed modification by December 30, 2025, to the primary contact, Llakim Dubroff, at llakim.dubroff@nih.gov.