Human Discovery Panel (HDP) analysis to obtain single cell multiomic data
ID: 75N95025Q00238SBType: Sources Sought
Overview

Buyer

HEALTH AND HUMAN SERVICES, DEPARTMENT OFNATIONAL INSTITUTES OF HEALTHNATIONAL INSTITUTES OF HEALTH NIDABethesda, MD, 20892, USA

NAICS

Testing Laboratories and Services (541380)

PSC

MEDICAL- LABORATORY TESTING (Q301)

Set Aside

Total Small Business Set-Aside (FAR 19.5) (SBA)

Original Source

https://sam.gov/opp/cb6356df686a41aea90bff0263e71608/view
Timeline
    Description

    The National Institute on Drug Abuse (NIDA), on behalf of the National Center for Advancing Translational Sciences (NCATS), is seeking capability statements from small businesses for a Human Discovery Panel (HDP) analysis aimed at obtaining single-cell multiomic data. The primary objective is to analyze transcriptomic and proteomic alterations during inflammatory sensitization in human pluripotent stem cell-derived sensory neurons, requiring vendors to prepare and sequence 33 samples using a single-cell multi-nomics platform that integrates RNA sequencing with DNA barcoded antibodies targeting up to 325 distinct proteins. This opportunity is crucial for advancing research in drug abuse and related fields, and responses are due by August 12, 2025, at 11:00 AM Eastern Time, with submissions directed to Andrew Varley at andrew.varley@nih.gov.

    Point(s) of Contact
    Andrew Varley
    (301) 827-5851
    andrew.varley@nih.gov
    Joshua T. Lazarus
    (301) 827-6923
    Josh.Lazarus@nih.gov
    Files
    Title
    Posted
    SBSSN.pdf
    The National Institute on Drug Abuse (NIDA), on behalf of the National Center for Advancing Translational Sciences (NCATS), has issued a Sources Sought Notice (Solicitation Number: 75N95025Q00239SB) for a Human Discovery Panel (HDP) analysis. This notice seeks capability statements from small businesses under NAICS code 541380 (Testing Laboratories and Services) to identify qualified vendors for single-cell multiomic data analysis. The objective is to obtain transcriptomic and proteomic alterations during inflammatory sensitization in human pluripotent stem cell-derived sensory neurons (hPSC-SNs). Vendors must be capable of preparing and sequencing 33 samples provided by NCATS, utilizing a single-cell multi-nomics platform that combines single-cell RNA sequencing with DNA barcoded antibodies targeting up to 325 distinct proteins. Required services include MultiPro Human Discovery Panel (Quantity 2), MultiPro Human Enhanced Blocking Reagent (Quantity 8), and Genomics Analysis Service (Quantity 1). Responses are due by August 12, 2025, at 11:00 AM, Eastern Time, via email to Andrew.Varley@nih.gov. This is not a solicitation for proposals, but rather an information-gathering effort to determine the appropriate acquisition method.
    Lifecycle
    Title
    Type
    Human Discovery Panel (HDP) analysis to obtain single cell multiomic data
    Currently viewing
    Sources Sought
    Similar Opportunities
    Support for Evaluating and Conducting Computational and Alternative Toxicological Methods for the National Institute of Environmental Health Sciences
    Buyer not available
    The Department of Health and Human Services, specifically the National Institute of Environmental Health Sciences (NIEHS), is seeking proposals from small businesses to support the evaluation and conduct of computational and alternative toxicological methods. The objective of this procurement is to assist NIEHS in chemical hazard and risk assessment while minimizing the use of animal testing, focusing on areas such as population variability, developmental neurotoxicity, and carcinogenicity. This contract, which is a Cost-Plus-Fixed-Fee type, has a base period of performance from June 1, 2026, to May 31, 2027, with nine additional one-year options and a potential six-month extension. Proposals are due by December 19, 2025, and must be submitted electronically via the NIH eCPS website; interested parties can contact Jason Williams at jason.williams2@nih.gov or Lisa Schaupp at lisa.schaupp@nih.gov for further information.
    A--Biologic Specimen and Data Repositories Information Coordinating Center (BioLIN
    Buyer not available
    The Department of Health and Human Services, specifically the National Institutes of Health (NIH), is seeking information regarding the Biologic Specimen and Data Repositories Information Coordinating Center (BioLINCC). This opportunity aims to gather insights on the capabilities and qualifications of potential contractors who can support the management and coordination of biologic specimen and data repositories. The services are critical for advancing health research and ensuring the integrity and accessibility of biological data for various studies. Interested parties can reach out to Natalie E. Bruning at natalie.bruning@nih.gov or by phone at +1 301 827 7528 for further details regarding this sources sought notice.
    TSA 2 Air System
    Buyer not available
    The Department of Health and Human Services, through the National Institutes of Health (NIH), is seeking proposals for the TSA 2 Air System, specifically a quantitative sensory testing device for the National Institute on Alcohol Abuse and Alcoholism (NIAAA). This procurement includes the Medoc Main Station, operating software, patient response unit, standard accessories, and remote setup and training support, all of which are critical for Dr. Joseph's clinical protocols. The contract is set aside for small businesses and will be evaluated based on technical requirements, price, and past performance, with a focus on non-price factors. Interested vendors must submit their proposals by December 14, 2025, and can direct inquiries to Kelly Robinson at kelly.robinson@nih.gov.
    Medication - Phenburane
    Buyer not available
    The Department of Health and Human Services, through the National Institutes of Health (NIH), is seeking proposals for the procurement of Phenburane, a medication classified under pharmaceutical preparation manufacturing. This solicitation aims to acquire a specific drug that plays a crucial role in medical treatments, particularly within the NIH's National Heart, Lung, and Blood Institute (NHLBI). Interested vendors should note that the primary contact for this opportunity is Brittany N. May, who can be reached at brittany.may@nih.gov or by phone at +1 301 594 4009 for further inquiries. Details regarding the funding amount and submission deadlines have not been specified in the provided information.
    EZ1 & 2 DNA Blood Isolation Kit and DNA Tissue Kit
    Buyer not available
    The Department of Health and Human Services, specifically the National Institutes of Health (NIH), intends to negotiate a sole source contract with Qiagen for the procurement of EZ1 & 2 DNA Blood Isolation Kits and DNA Tissue Kits. These kits are critical for the ongoing clinical research and patient care at the NIH Clinical Center, particularly for Human Leukocyte Antigen (HLA) matching in transplant patients and potential donors. The kits have been extensively tested and are essential for providing high-quality DNA samples necessary for critical Next Generation Sequencing, with an estimated contract value of $29,166.25. Interested parties may submit capability statements by email to valerie.gregorio@nih.gov by 11:00 AM EST on December 13, 2025, referencing NOI-CC-26-000013.
    IPA Analysis Match Explorer CL
    Buyer not available
    The National Institute of Environmental Health Sciences (NIEHS), part of the Department of Health and Human Services, intends to negotiate a sole source contract with Qiagen, LLC for the IPA Analysis Match Explorer CL software, which is essential for their research needs. This unique software requirement is deemed to have only one responsible source capable of fulfilling the government's specifications, highlighting its critical role in NIEHS's operations. The contract is set for a performance period from January 1, 2026, to December 31, 2027, and interested parties who believe they can meet the requirements are encouraged to submit a capability statement by December 12, 2025, at 12:00 PM EST to Joseph Williams at joseph.williams2@nih.gov. No solicitation package is available, and the government's decision on whether to pursue a competitive procurement will be based on the responses received.
    The National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) Seeks Industry Partners for Clinical Research Collaborations on Therapeutics, Diagnostics or Devices for Childhood Cholestatic Liver Diseases
    Buyer not available
    The National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) is seeking industry partners for clinical research collaborations focused on therapeutics, diagnostics, or devices for childhood cholestatic liver diseases. The initiative aims to engage collaborators in providing novel therapeutic agents and diagnostic tools for use in NIH-sponsored multi-center clinical trials targeting conditions such as biliary atresia and alpha-one antitrypsin deficiency, among others. This collaboration is critical for advancing research and improving clinical outcomes for children suffering from these rare liver diseases. Interested organizations must submit a Capability Statement detailing their proposed solutions and capabilities, with no funding provided by NIDDK for this opportunity. For inquiries, contact Edward Doo at dooe@niddk.nih.gov or Katrina Loh at katrina.loh@nih.gov.
    A--Pre-Sol Notice of Intent
    Buyer not available
    The Department of Health and Human Services, specifically the National Institutes of Health (NIH), has issued a Pre-Solicitation Notice of Intent regarding upcoming procurement opportunities. This notice pertains to research and development services in the physical, engineering, and life sciences sectors, as indicated by the NAICS code 541715. The services sought are crucial for advancing health-related research and healthcare services, contributing to the overall mission of the NIH. For further inquiries, interested parties can contact Lynn M. Furtaw at lynn.furtaw@nih.gov or by phone at +1 301 435 0330.
    Biospecimen Core Resource
    Buyer not available
    The Department of Health and Human Services, specifically the National Institutes of Health (NIH) under the National Cancer Institute (NCI), is seeking to establish a Biospecimen Core Resource (BCR) to support various biospecimen-related activities. The BCR will operate under documented Standard Operating Procedures (SOPs) to facilitate the collection, processing, distribution, and storage of biospecimens as outlined in NCI Task Orders. This initiative is crucial for advancing cancer research and ensuring the integrity and availability of biospecimens for scientific studies. Interested parties can reach out to Apisit Viriya at apisit.viriya@nih.gov or Mataya Robinson at mataya.robinson@nih.gov for further details regarding this opportunity.
    Q301--Metabolomics and Lipidomics Pulmonary Study
    Buyer not available
    The Department of Veterans Affairs is soliciting proposals for a Metabolomics and Lipidomics Pulmonary Study, focusing on the analysis of 185 human samples. This contract, designated for Small Businesses under NAICS code 541714, aims to enhance understanding of pulmonary conditions through advanced biochemical analysis. The performance period for the contract is set from December 31, 2025, to December 30, 2026, with proposals due by December 15, 2025, at 10:00 AM MST. Interested vendors should direct inquiries to Contract Specialist Felicia L. Simpson at felicia.simpson@va.gov and ensure compliance with all registration and documentation requirements to facilitate timely processing.