The Department of Defense, specifically the Department of the Air Force, has issued a Combined Synopsis/Solicitation notice for the AFWERX Challenge Commercial Solutions Opening (CSO). This CSO is part of the AFWERX Challenge Program and individual Calls against the CSO will be posted under this notice, as well as afwerxchallenge.com. The CSO is seeking commercial solutions for national defense R&D services, atomic energy defense activities, and applied research.