PRECLINICAL MEDICATIONS SCREENING IN DEPENDENCE MO
ID: 75N94024R00003Type: Solicitation
Overview

Buyer

HEALTH AND HUMAN SERVICES, DEPARTMENT OFNATIONAL INSTITUTES OF HEALTHNATIONAL INSTITUTES OF HEALTH NICHDBETHESDA, MD, 20817, USA

NAICS

Research and Development in the Physical, Engineering, and Life Sciences (except Nanotechnology and Biotechnology) (541715)

PSC

GENERAL SCIENCE AND TECHNOLOGY R&D SERVICES; GENERAL SCIENCE AND TECHNOLOGY; BASIC RESEARCH (AJ11)

Original Source

https://sam.gov/opp/ed0e523fb8dd41a880ef015c5c0f7de6/view
Timeline
    Description

    The Department of Health and Human Services, specifically the National Institutes of Health (NIH), is seeking proposals for a contract focused on preclinical medications screening in models of Alcohol Use Disorder (AUD). The objective of this procurement is to conduct blind testing of compounds supplied by developers using mouse models, with the contractor responsible for generating analyses and reports throughout the project. This initiative is crucial for advancing research in alcohol use disorder treatments and ensuring compliance with NIH policies on reproducibility and animal welfare. Proposals are due by September 18, 2024, with the contract period commencing on December 1, 2024, and extending through November 30, 2031. Interested parties can contact Lisa Schaupp at lisa.schaupp@nih.gov or 301-827-8135 for further information.

    Point(s) of Contact
    SCHAUPP, LISA L
    (301) 827-8135
    lisa.schaupp@nih.gov
    Files
    Title
    Posted
    Amend_01_Att_01_02_03_RFP_75N94024R00003_8_23_24_0001.pdf
    Amendment 01 to RFP 75N94024R00003 outlines special contract requirements regarding information and physical security for government-owned/contractor-operated (GOCO) and contractor-owned/contractor-operated (COCO) systems. Key provisions include compliance with federal security regulations, including the HHS Information Security and Privacy Policy and NIST guidelines. Contractors must obtain a valid Authority to Operate (ATO) within three months post-award, and submit a System Security Plan (SSP) and Plan of Action and Milestones (POA&M) detailing security controls and vulnerability management. Furthermore, contractors must ensure continuous monitoring of IT assets, apply secure coding practices, and facilitate government access for security assessments. The document specifies guidelines for end-of-life software, use of secured devices, data rights, and cybersecurity supply chain risk management. Additionally, contractors are mandated to comply with Section 508 of the Rehabilitation Act regarding electronic accessibility of deliverables. The contract concerns a preclinical testing program for drugs aimed at treating Alcohol Use Disorder and is set to begin on December 1, 2024, lasting 12 months with six options for extension. This RFP emphasizes the government's commitment to upholding stringent security and accessibility standards in conjunction with advancing public health research.
    att_24_links.pdf
    The document is a compilation of attachments and resources related to federal and state/local Request for Proposals (RFPs) for the National Institutes of Health (NIH). It includes various essential components required for proposal submissions, such as guidelines for proposal packaging, intent response sheets, a statement of work for an Indefinite Delivery Indefinite Quantity (IDIQ) contract, and specified reporting requirements and deliverables. Additional key items consist of technical proposal forms, cost summary links, and compliance certifications, along with instructions for invoicing and financial requests. Furthermore, it outlines specific templates for small business subcontracting plans, government property scheduling, and employee suitability investigations. The document emphasizes the necessity of safeguarding non-public information through contractor agreements. Task orders, including statements of work for pre-clinical contract administration and compound testing, are also described. The comprehensive nature of these attachments indicates a structured approach to facilitate proposals, ensuring clarity and adherence to federal guidelines, thereby supporting the government's procurement processes. This intricate framework reinforces the commitment to maintain robustness and transparency in public spending.
    Presolicitation_Notice_75N94024R00003_PreClinical_Dependency_Mice_2.pdf
    SBCX_Industry_Subcontracting_Guide_0002.pdf
    The "HHS Industry User Guide for Subcontracting Plan Reviews" serves as a comprehensive manual for vendors required to submit subcontracting plans to the Department of Health and Human Services (HHS). The document outlines the process for accessing and reviewing subcontracting plans through the SBCX platform, which includes sections for project information, subcontracting goals, documentation, and communication with HHS officials. Vendors are guided to identify the type of subcontracting plan, report eligible subcontracting expenditures, provide necessary goal data, designate a Subcontracting Program Administrator, and detail efforts to include small businesses. They must certify compliance and submit the plan for approval. The evaluation process involves multiple approvers, ensuring thorough oversight. The guide emphasizes the importance of compliance with subcontracting goals within the context of federal and local RFPs, aligning with broader government objectives to engage small businesses in federal contracting opportunities. The document ultimately facilitates a structured approach to subcontracting plan submissions and reviews, ensuring adherence to government standards.
    Sol_75N94024R00003_Amd_0001.pdf
    The document serves as an amendment to solicitation number 75N94024R00003 issued by the National Institute of Child Health (NICHD), detailing modifications to the initial request related to a contract for "Preclinical Medications Screening in Dependence Models of Alcohol Use Disorder." Key updates include the addition of a new section on information security, revisions to Section M.6 for compliance with Section 508 guidelines, and amendments to Attachment 21 to include the necessary Section 508 language. The performance period for the contract is specified from December 1, 2024, to November 30, 2031. In accordance with federal requirements, offers must acknowledge receipt of this amendment to avoid rejection. The document emphasizes adherence to rigorous standards for information security and accessibility, reflecting the government’s commitment to ensuring equitable access to information and services in the procurement process. This amendment is a formal step in the federal contracting process, aligning with guidelines for soliciting offers and modifying existing contracts.
    Sol_75N94024R00003_Amd_0002.pdf
    The document pertains to Amendment 02 of Solicitation No. 75N94024R00003 issued by the National Institute of Child Health (NICHD), part of the National Institutes of Health (NIH). The amendment outlines important procedural guidelines for potential offerors, emphasizing the necessity of acknowledging receipt of the amendment by a specified date to avoid the rejection of offers. The primary focus is on the solicitation titled "Preclinical Medications Screening in Dependence Models of Alcohol Use Disorder," with a performance period set from December 1, 2024, to November 30, 2031. Key changes in this amendment include provisions for submitting written questions to Ms. Sarah Bank by September 4, 2024, and inclusion of a guide for subcontracting plan reviews. It also updates a specific section to incorporate a link for the SBCX Subcontracting Plan Review. The document reinforces the need for compliance with the call for amendments and modifications applicable to governmental contracts, highlighting the importance of clear communication and documentation in federal contract procedures. Overall, it serves as a crucial resource for contractors interested in the mentioned solicitation, facilitating clarity and proper protocol adherence in the submission process.
    Sol_75N94024R00003.pdf
    The National Institutes of Health (NIH) issued a Request for Proposals (RFP) for a contract related to preclinical medication screening in models of Alcohol Use Disorder (AUD). The project aims to conduct blind testing of compounds supplied by developers in mice, with analyses and reports to be generated. Proposals are due by September 18, 2024, and the contract period spans from December 1, 2024, to November 30, 2031. This contract, accessible to various small businesses, outlines estimated costs, payment terms, and specific performance requirements, including adherence to NIH policies on reproducibility, animal welfare, and financial conflicts of interest. The contractor will provide all necessary personnel and resources, submitting regular progress reports and ensuring compliance with federal procurement regulations. Rigorous standards for monitoring and response to conflicts of interest are established, emphasizing the contractor’s accountability for transparent research practices. The successful offeror will engage in a structured process for task orders, ensuring alignment with NIH directives and the overall mission of advancing alcohol research.
    Sources_Sought_75N94024R00003_1.pdf
    Statement_of_Work_dated_2_14_2024_1.pdf
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