The Department of Health and Human Services, specifically the Centers for Disease Control and Prevention (CDC), is conducting a Request for Information (RFI) to explore managed cloud hosting options for public health applications. The objective is to gather insights on potential cloud service providers that can support the hosting of various public health tools and applications, which are critical for disease surveillance and data management across state, tribal, local, and territorial public health departments. This initiative aims to enhance the efficiency and effectiveness of public health data integration and surveillance systems, ensuring timely access to vital health information. Interested parties are encouraged to submit their responses by 4:00 PM EST on November 30, 2025, to Jasmine Powell at jpowell5@cdc.gov.