The Defense Advanced Research Projects Agency (DARPA) is issuing a Request for Information (RFI) to gather insights on advanced medical technologies for Combat Casualty Care (CCC) in challenging environments. This RFI aims to solicit input from industry, academia, government laboratories, and non-traditional performers regarding innovative medical sensing, computational, modeling, actuation, therapeutic, and robotics technologies that can enhance care from point-of-injury through prolonged and surgical care. The focus is on capabilities that can provide rapid diagnosis, predictive modeling, automated interventions, and resilience in resource-constrained settings. Interested parties should note that the deadline for submissions has been revised to December 17, 2025, at 4:00 PM ET, and can direct inquiries to Dr. Roozbeh Jafari at CCCxBTO@darpa.mil.