Automated Cell Dissociation Apparatus
ID: 75N95025Q00116Type: Combined Synopsis/Solicitation
Overview

Buyer

HEALTH AND HUMAN SERVICES, DEPARTMENT OFNATIONAL INSTITUTES OF HEALTHNATIONAL INSTITUTES OF HEALTH NIDABethesda, MD, 20892, USA

NAICS

Analytical Laboratory Instrument Manufacturing (334516)

PSC

LABORATORY EQUIPMENT AND SUPPLIES (6640)
Timeline
  1. 1
    Posted Mar 10, 2025, 12:00 AM UTC
  2. 2
    Updated Mar 10, 2025, 12:00 AM UTC
  3. 3
    Due Mar 14, 2025, 1:00 PM UTC
Description

The Department of Health and Human Services, specifically the National Institutes of Health (NIH), is seeking to procure an Automated Cell Dissociation Apparatus to enhance research capabilities in neurodegenerative diseases. The apparatus, specifically the S2 Genomics Singulator 100 Cell Dissociation Platform, is required to facilitate the isolation of single nuclei from human and mouse brain tissues, supporting various cell types while ensuring fast and reproducible tissue dissociation. This procurement is critical for advancing scientific research in areas such as ALS, Parkinson's, and Alzheimer's diseases. Interested vendors should contact Rashiid Cummins at rashiid.cummins@nih.gov, with delivery expected within 60 days post-award.

Point(s) of Contact
Files
Title
Posted
Mar 10, 2025, 12:05 PM UTC
The document outlines the Representation Regarding Certain Telecommunications and Video Surveillance Services or Equipment as prescribed under federal regulations. It mandates that Offerors must disclose their use or provision of covered telecommunications equipment or services when submitting bids for government contracts. The prohibition on such equipment stems from the John S. McCain National Defense Authorization Act for Fiscal Year 2019, aimed at enhancing national security by restricting the procurement of potentially compromised telecommunications technologies. Offerors are required to check the System for Award Management (SAM) for entities excluded from receiving federal awards related to covered equipment or services. The provision details the definitions, prohibitions, and necessary disclosures tied to the representations that Offerors must provide. This regulation emphasizes compliance and transparency regarding telecommunications contracts, ensuring that entities engaging with the government do not introduce security vulnerabilities through their supply chains.
Mar 10, 2025, 12:05 PM UTC
The document outlines the federal representation requirements related to "covered telecommunications equipment or services" applicable to government contracts. It defines key terms referenced in clause 52.204-25, which prohibits contracting for certain telecommunications and video surveillance services or equipment. Offerors must consult the System for Award Management (SAM) to identify excluded parties related to these services. The primary representation required from the Offeror confirms whether they provide such equipment or services in their offerings to the government and whether they use any systems that utilize covered telecommunications equipment after conducting a reasonable inquiry. This representation must be certified by an authorized individual from the organization, ensuring accountability and compliance with federal regulations. The focus on covered telecommunications equipment is relevant to the integrity and security of government contracts, reinforcing the government's stance on avoiding high-risk technologies in its procurement processes.
Mar 10, 2025, 12:05 PM UTC
This document serves as an addendum to FAR 52.212-4, detailing terms and conditions for commercial items contracts. It establishes a hierarchy for resolving inconsistencies in contracts, beginning with the schedule of supplies and services, followed by various clauses and documents associated with the contract. Key elements include the definition and treatment of commercial supplier agreements, emphasizing their legal binding nature and the specific terms applicable to U.S. Government contracts. Significant clauses include stipulations regarding applicability, governing law, dispute resolution, audit rights, indemnification, and confidentiality. The addendum ensures that any changes to supplier agreements must not materially affect government obligations unless documented properly. Automatic renewals of services require explicit consent from government representatives, and any taxes or surcharges intended for government contracts must be determined by the contracting officer. Overall, this addendum outlines important legal protections and requirements that govern the procurement of commercial items by federal agencies, aiming to ensure compliance, accountability, and clarity in contract management.
This document outlines the mandatory Federal Acquisition Regulation (FAR) clauses incorporated into a government contract, ensuring compliance with applicable laws and Executive orders related to the acquisition of commercial products and services. Key clauses include stipulations on subcontractor sales restrictions, contractor business ethics, whistleblower protections, and various small business considerations, such as set-asides and subcontracting plans. Notable regulations also address prohibitions against contractors using certain telecommunications services and mandates for veteran and disability employment opportunities. Additionally, the document specifies requirements for transparency in contractor reporting and the promotion of sustainability in procurement practices. By enforcing these regulations, the contract aims to uphold integrity, encourage small business participation, and ensure fair labor practices within government procurement processes.
Mar 10, 2025, 12:05 PM UTC
The document outlines the requirements for offerors responding to a federal solicitation regarding Information and Communication Technology (ICT) accessibility, specifically compliance with Section 508 standards. Offerors must submit a completed HHS Section 508 Accessibility Conformance Checklist or an Accessibility Conformance Report (ACR) using the Voluntary Product Accessibility Template (VPAT) to demonstrate how their ICT products and services meet these standards. If accepted supplies and services later fail to conform to the stated accessibility criteria, the contractor is responsible for necessary remediation at their expense. Offerors are also required to provide sufficient information on any inability to meet Section 508 requirements. Additionally, all electronic content delivered must align with HHS acceptance criteria and accompany the appropriate checklist, unless exempted by the Contracting Officer. This document emphasizes the importance of accessibility in government procurement to ensure ICT solutions are usable by individuals with disabilities, reflecting the government's commitment to inclusivity.
Mar 10, 2025, 12:05 PM UTC
The document outlines a clause regarding Information and Communication Technology (ICT) Accessibility, emphasizing compliance with Section 508 of the Rehabilitation Act. It mandates that all ICT products and services developed, acquired, or delivered under the contract must meet the Revised 508 Standards for accessibility. Contractors are tasked with ensuring that their ICT offerings conform, and any non-compliance requires them to handle remediation at their own cost. For contract modifications or task orders involving new ICT, contractors must submit accessibility checklists or conformance reports to verify compliance. Additionally, contractors must disclose any exceptions to the Section 508 requirements, ensuring transparency in their obligations for accessibility. This clause is significant within the context of government RFPs and grants, reinforcing the federal commitment to making technology accessible for individuals with disabilities.
The National Institute on Aging (NIA) seeks to procure an automated cell dissociation apparatus to facilitate single nuclei isolation from human and mouse brain tissues, aiding in research on neurodegenerative diseases such as ALS, Parkinson's, and Alzheimer's. The chosen product is the S2 Genomics Singulator 100 Cell Dissociation Platform, which must fit on a bench-top, utilize single-use cartridges, and enable fast, reproducible tissue dissociation into cell or nuclei suspensions. It should support various cell types from multiple tissue sources and avoid lengthy centrifugation processes. Additionally, the platform's software must allow customization of processing parameters, such as mincing and enzyme incubation conditions. The delivery is expected within 60 days post-award. This request underscores the NIA's commitment to advancing scientific research through innovative laboratory technology.
The National Institute on Aging (NIA), Laboratory of Neurogenetics (LNG) seeks an automated cell dissociation apparatus specifically for isolating single nuclei from human and mouse brain tissues. This acquisition aims to advance research on neurodegenerative diseases such as amyotrophic lateral sclerosis (ALS), Parkinson's disease, and Alzheimer's disease, facilitating future single-cell sequencing studies. The preferred model is the S2 Genomics Singulator 100 Cell Dissociation Platform, which must meet several specific requirements, including bench-top compatibility, single-use cartridges, and the ability to produce rapid and reproducible single-cell or nuclei suspensions from various tissue sources. The apparatus should employ pre-set protocols for cell nuclei isolation and feature customizable software to adjust parameters like enzyme incubation times and mechanical disruption methods. The delivery of this equipment is expected within 60 days following the award. The request underscores the NIA's commitment to furthering scientific understanding of neurodegenerative diseases through advanced technological tools.
Lifecycle
Title
Type
Combined Synopsis/Solicitation
Sources Sought
Similar Opportunities
iNDI ALFAtag cell lines for the iPSC Neurodegenetive Disease Initiative (iNDI) project
Buyer not available
The Department of Health and Human Services, specifically the National Institutes of Health (NIH), is seeking proposals for the procurement of iNDI ALFAtag cell lines as part of the iPSC Neurodegenerative Disease Initiative (iNDI) project. The objective is to generate up to 230 isogenic iPSC cell lines, including fluorescent ALFAtags for visualization, adhering to established quality control standards for research on Alzheimer's disease and related dementias. This initiative is crucial for advancing scientific understanding of neurodegenerative diseases and creating a publicly accessible cell repository. Interested vendors must submit their proposals by April 15, 2025, at 12:00 PM Eastern Time, to Andrea Clay at amcgee@nih.gov, referencing solicitation number 75N95025Q00078.
SOURCES SOUGHT: Maintenance and Repair Service for an Automated Liquid Handling System
Buyer not available
The Department of Health and Human Services, specifically the National Institutes of Health (NIH), is seeking qualified small businesses to provide maintenance and repair services for a Microlab VANTAGE 1.3 Automated Liquid Handling System utilized by the National Institute on Aging (NIA) for neurodegenerative disease research. The procurement aims to ensure the system's continuous operation through preventative maintenance, repairs, and software updates, with a contract period spanning from June 17, 2025, to June 16, 2029, including options for extensions. This specialized maintenance support is critical for facilitating ongoing research efforts in Alzheimer's and related dementias, adhering to federal regulations and performance standards. Interested parties must submit their capability statements to Rashiid Cummins at rashiid.cummins@nih.gov by April 8, 2025, at 9:00 am Eastern Time.
Notice of Intent BD Rhapsody Single-Cell Analysis Reagent Kits
Buyer not available
Notice of Intent BD Rhapsody Single-Cell Analysis Reagent Kits The Department of Health and Human Services, Department of, National Institutes of Health, is planning to procure BD Rhapsody Single-Cell Analysis Reagent Kits. These kits are used for the manufacture of human cells and tissue-based products utilized in phase I/II clinical protocols for transplantation, adoptive immunotherapy, and gene therapy conducted in the Clinical Center at the NIH. The procurement includes a standing order for multi-type sequencing kits and reagents with a short shelf life. The contractor will be responsible for shipping the sufficient reagents and kits following the scheduled delivery dates. The shelf life of the sequencing reagents should be at least 3 months, and the shelf life of library generation kits should be at least 6 months. The contractor is also required to provide technical support for all kits and reagents at no additional cost. The period of performance for this procurement is from 5/1/2024 to 8/30/2024. The delivery schedule is overnight delivery Monday through Thursday to the Center for Cellular Engineering (CCE) at NIH/CC in Bethesda, MD. The vendor will be responsible for ensuring the safe transport of cryopreserved patient cells and maintaining the temperature and other parameters during the shipment of reagents and kits. The contractor will be paid per product delivered and is required to provide hard copies of proofs of each product delivered. Interested parties can submit their capabilities to the Office of Purchasing and Contracts by May 1st, 9:00 AM EST. Please note that this is not a request for proposal.
SOURCES SOUGHT: Signatures of aging outcomes
Buyer not available
The Department of Health and Human Services, specifically the National Institutes of Health (NIH), is seeking qualified small business contractors to perform comprehensive immunohistochemistry analysis of 2,184 mice tissue samples as part of a project aimed at identifying age-associated phenotypic changes in various organs. The objective is to build proteomic signatures of aging outcomes through detailed histological analysis, which includes tasks such as tissue trimming, cassette preparation, paraffin embedding, sectioning, staining, and imaging. This initiative is crucial for advancing the understanding of aging and its effects on health, and the selected contractor will be required to provide progress reports and deliver electronic images and stained slides within one year of sample receipt. Interested parties must submit their capability statements to Rashiid Cummins at rashiid.cummins@nih.gov by April 4, 2025, at 9:00 am Eastern Time, adhering to specified formatting guidelines.
MAINTENANCE SERVICES FOR THERMOFISHER MANUFACTURED CENTRIFUGES & INCUBATORS
Buyer not available
The Department of Health and Human Services, specifically the National Institutes of Health (NIH) through its National Institute of Allergy and Infectious Diseases (NIAID), is seeking maintenance services for 23 incubators and 16 centrifuges located in Bethesda, Maryland. The procurement requires priority onsite repair during business hours, annual preventive maintenance, rapid response for corrective repairs, and unlimited phone and email support, emphasizing the critical role of these laboratory instruments in health research. Interested vendors must provide OEM authorization to deliver these services and be registered in the System for Award Management (SAM), with quotes due by April 10, 2025, under solicitation number RFQ-NIAID-25-2257534. For further inquiries, vendors can contact Leah Hinson at leah.hinson@nih.gov.
Plasma assays of Alzheimer’s disease biomarkers (abeta42, abeta40, ptau217 ) using the Lumipulse assays on the Fujirebio G1200 in the Baltimore Longitudinal Study of Aging (BLSA)
Buyer not available
The Department of Health and Human Services, specifically the National Institutes of Health (NIH), is seeking a contractor to perform plasma assays of Alzheimer’s disease biomarkers (abeta42, abeta40, ptau217) using Lumipulse assays on the Fujirebio G1200 for the Baltimore Longitudinal Study of Aging (BLSA). The contractor will analyze approximately 4,000 serum/plasma samples, employing senior research specialists to ensure continuity and consistency with prior assays, ultimately contributing to the understanding of cognitive decline and Alzheimer’s disease. This procurement is critical for advancing research on early identification and treatment of Alzheimer’s and related dementias, with a contract period anticipated from May 1, 2025, to April 30, 2026. Interested parties must submit their proposals by 9:00 a.m. EDT on April 11, 2025, to Emily Palombo at emily.palombo@nih.gov.
65--Cage & Rack Washer
Buyer not available
The Department of Health and Human Services, through the National Institutes of Health (NIH), is seeking information from small businesses regarding a procurement opportunity for a cage and rack washer to support laboratory animal care at the National Institutes of Diabetes and Digestive and Kidney Diseases (NIDDK). This acquisition aims to replace an outdated system with a new, firm-fixed price model that integrates into existing infrastructure and includes operator training during startup. The cage and rack washer is vital for maintaining hygiene and health standards for laboratory rodents, which is essential for ensuring high-quality research outcomes. Interested small businesses are encouraged to submit a capability statement detailing their firm size, relevant experience, and references by April 9, 2025. For further inquiries, contact Airron Wiggins at airron.wiggins@nih.gov or call +1 410 504 9360.
A--Repository of Mouse Models for Down Syndrome
Buyer not available
The Department of Health and Human Services, through the National Institutes of Health (NIH) and specifically the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD), is announcing its intent to negotiate a sole-source contract with Jackson Laboratory for the establishment and maintenance of a Repository of Mouse Models for Down Syndrome. This initiative aims to produce, acquire, maintain, and distribute genetically characterized mouse models, particularly focusing on the Ts65Dn strain, to support cytogenetic research related to Down syndrome. The contractor will also be responsible for essential tasks such as cryopreservation, pathogen testing, and phenotypic characterization, with ongoing consultations with a Scientific Advisory Board to align with the research community's needs. Interested parties are encouraged to submit capability statements by the specified deadline, as this contract is anticipated for one year with options for four additional periods, and is not currently open for competitive proposals. For further inquiries, contact Dana L. Harris at harrisd@mail.nih.gov or +1 301 443 7798.
SOURCES SOUGHT: Maintenance and Repair Service for Tecan Robotic Manipulator Arm (RoMa)
Buyer not available
The Department of Health and Human Services, specifically the National Institutes of Health (NIH), is seeking qualified small businesses to provide maintenance and repair services for a Tecan Robotic Manipulator Arm (RoMa) used by the National Institute on Aging (NIA). The objective is to ensure the continued functionality of this critical laboratory equipment, which supports ongoing genotyping research, through comprehensive maintenance support, including preventative maintenance, software upgrades, and technician training. Interested companies must submit a capability statement detailing their qualifications, including employee count and relevant experience, by April 7, 2025, at 11 AM Eastern Time, to Hashim Dasti at hashim.dasti@nih.gov. This opportunity is not a solicitation for proposals but a means to gauge the availability of qualified small business sources.
Purchase of Lab Supplies
Buyer not available
The Department of Health and Human Services, specifically the National Institutes of Health (NIH), is seeking qualified vendors to provide various lab supplies, including cleaning and sanitation products, under solicitation number 75N98025Q00021. The procurement aims to ensure the NIH is equipped with essential supplies such as paper towels, disinfectant wipes, and hand soap, which are critical for maintaining hygiene and safety in healthcare environments. This opportunity includes a partial small business set-aside, encouraging participation from small businesses, including service-disabled veteran-owned and women-owned enterprises, with a focus on timely delivery within a 10-day timeframe. Interested vendors must submit their quotes via email by 4:30 PM Eastern Daylight Time on April 9, 2025, and can direct inquiries to Carol Hayden at haydenc@od.nih.gov.