Special Notice: ENERGY, DEPARTMENT OF is seeking proposals for the INL Innovation Spotlight Cyber Resilient Trade-off Evaluation (CyRTE): Pioneering Strategy for Operational Technology Security. CyRTE is a groundbreaking approach to evaluate and enhance the cyber resilience of Operational Technologies (OT), balancing security measures with operational integrity. It provides a resilience-informed, AI-driven process to assess the impact of cybersecurity mitigations on the operation and stability of OT systems. This technology is essential for evaluating automated responses in advance of application, benefiting industries such as utilities, manufacturing, and transport, where operational technology is critical. CyRTE offers a novel methodology for assessing cyber-physical interactions and their implications on OT systems. It involves a comprehensive evaluation of potential cybersecurity mitigations and their effects on system performance and reliability. The core of CyRTE is the creation of a "buzzer" concept – a unique tool that systematically tests the resilience of OT systems against various cyber-physical response strategies. It is applicable across various sectors reliant on operational technologies, including critical infrastructure systems, manufacturing and industrial control systems, utilities and energy sector, chemical and process industries, and research and development in cybersecurity for operational technologies. The technology is currently at Technology Readiness Level (TRL) 2 and has a US Patent Application. For more information and to engage with this innovation, please contact Andrew Rankin at td@inl.gov.