The Department of Health and Human Services (HHS), through the National Institutes of Health (NIH) and the National Institute on Drug Abuse (NIDA), is seeking qualified small businesses to provide professional services under the HHS One Professional Services Solution (HOPSS). The procurement aims to support HHS's strategic goals from 2022 to 2026, focusing on enhancing healthcare access, improving public health outcomes, and fostering equity through two primary task areas: Science, Technology, Engineering and Math (STEM) services, and Business and Operational Services to support STEM activities. This initiative is critical for advancing research and operational efficiencies across various HHS divisions, with a total contract value anticipated to be significant, as it builds on a history of complex service contracts. Interested small businesses must submit a written capability statement and complete a mandatory survey by December 9, 2024, at 1:00 PM ET, with further inquiries directed to Kyle Miller at kyle.miller2@nih.gov.