The Department of Health and Human Services, specifically the National Institutes of Health (NIH) and The Centers for Disease Control and Prevention (CDC), are seeking proposals for Small Business Innovation Research (SBIR) contract proposals. The specific topic of the solicitation is "Organ-on-Chip for Preclinical and Translational Radiobiological Studies".
The technology being solicited is the development and integration of advanced Organ-on-Chip (OoC) systems into cancer treatment development and translational pipelines in radiobiology and drug radiation combination studies. OoC systems are microfluidic devices that mimic tissue and tumor microenvironments, providing physiologically and clinically relevant models for preclinical radiobiological research. These models have the potential to improve the prediction of drug-radiation combination efficacy and toxicities, determine the relative biological effectiveness of proton therapy, and reduce the cost of research by improving preclinical research quality and potentially reducing animal use.
Fast-Track proposals and Direct-to-Phase II proposals will be accepted. The anticipated number of awards is 2-3. The budget for Phase I is up to $400,000 for up to 12 months, and the budget for Phase II is up to $2,000,000 for up to 2 years. Proposals that exceed the budget or project duration listed may not be funded.
Overall, this solicitation aims to accelerate the development and validation of advanced OoCs for preclinical and translational radiobiological studies, with the potential to impact cancer treatment development and other areas of cancer research.