The Department of Defense (DOD) is seeking proposals for innovative solutions to mitigate ethylene oxide (ETO) used in sterilization processes. The goal is to promote environmentally friendly and sustainable practices in the field of sterilization technologies. ETO is commonly used in the manufacturing of medical devices for its effective sterilization properties, but its use raises environmental and health concerns due to its potential carcinogenicity. The DOD is specifically looking for advancements in sterilization technologies that prioritize environmental sustainability and health by minimizing or eliminating ethylene oxide emissions during medical device sterilization. The technology should be compatible with current ETO sterilization equipment and processes, and should not require significant alterations to existing setups. The proposal should include a plan for FDA clearance and EPA review, and the technology should be operable with little training or background. The project will have a Phase I feasibility study followed by a Phase II development and refinement of the solution. The Phase II focus includes prototype development, efficacy testing, regulatory compliance, and a scale-up strategy or commercialization plan. The ultimate goal is to transition the ETO mitigation solution into widespread implementation across diverse industries, including medical, pharmaceutical, food, laboratory, veterinary, cosmetic, and textile sectors. The small business should have plans to secure funding from non-SBIR government sources and/or the private sector to develop or transition the prototypes into a viable product for sale to the military and/or commercial markets. The successful implementation of the ETO mitigation solution will contribute to a safer and more sustainable future for medical device manufacturing.