Host Directed Therapeutics for treatment for viral disease – Open Topic
ID: CBD244-P001Type: BOTH
Overview

Topic

Host Directed Therapeutics for treatment for viral disease – Open Topic

Agency

Agency: DODBranch: CBD

Program

Type: SBIRPhase: BOTH

Topic Link

https://www.dodsbirsttr.mil/topics-app/

Additional Information

https://www.dodsbirsttr.mil/topics-app/
Timeline
    Description

    The Department of Defense (DOD) is seeking innovative solutions for Host Directed Therapeutics (HDTs) aimed at treating viral diseases, as part of its Small Business Innovation Research (SBIR) program. The objective is to develop and demonstrate the efficacy of broadly active HDTs that can serve as treatments or prophylactic measures against infections from various viral families, including Filoviruses, Togaviruses, and Hantaviruses. This initiative addresses significant gaps in treatment options for serious viral infections, with the potential for applications in both civilian and military populations. The solicitation is currently closed, with the next opportunity opening on August 22, 2024, and applications due by September 24, 2024. For more information, interested parties can visit the DOD SBIR website at https://www.dodsbirsttr.mil/topics-app/.

    Files
    Title
    Posted
    1729929013728.pdf
    Similar Opportunities
    Novel Materials & Material Configurations -
    Active
    DOD
    The Department of Defense (DOD) is launching the OSD254-002 Small Business Innovation Research (SBIR) initiative, aimed at identifying and developing novel materials and material configurations to enhance military operations. This opportunity seeks innovative prototypes that demonstrate unique properties, such as advanced optical or electromagnetic characteristics and superior environmental responses, with a focus on scalability and manufacturability. The program is structured in three phases: Phase I involves the development and validation of proposed materials, Phase II focuses on prototype demonstration and independent assessments, and Phase III aims to operationalize these innovations for both military and civilian applications. Interested parties can find more information and submit proposals through the DOD SBIR website, with the solicitation opening on December 4, 2024, and closing on January 8, 2025.
    Innovations in Improving Affordability, Producibility, and Scalability of High Temperature Resistant, Thermal Protection System (TPS) Materials, Processing, Structures Manufacturing, and Resilient Supply Chains for Conventional Hypersonic Weapons and Related Defense System Applications -
    Active
    DOD
    The Defense Logistics Agency (DLA) is seeking innovative solutions to enhance the affordability, producibility, and scalability of high-temperature resistant Thermal Protection System (TPS) materials, which are critical for conventional hypersonic weapons and related defense applications. The initiative aims to strengthen domestic production capabilities and supply chain resilience while addressing challenges such as cost reduction, increased production efficiency, and risks associated with foreign reliance. The R&D effort will unfold in multiple phases, with Phase I focusing on demonstrating feasibility at Technology Readiness Levels (TRL) 3-6, with a funding limit of $306,872 over a 12-month period. Interested parties should note that the solicitation will open on December 4, 2024, and proposals are due by January 8, 2025, with further details available at the DOD SBIR/STTR website.
    Phase I Open Call for Small Business Closing Supply Chain Gaps for Aging Weapon Systems -
    Active
    DOD
    The Defense Logistics Agency (DLA) is inviting proposals from small businesses through the SBIR program to address supply chain gaps for Aging Weapon Systems. The initiative aims to enhance the Small Business Manufacturer (SBM) industrial base by focusing on the manufacturing of specific National Stock Numbers (NSNs) without integrated software solutions, thereby supporting mission readiness and logistics. This opportunity is structured in three phases, with Phase I allowing for a budget of $50,000 over six months to qualify as a DLA source, and Phase II extending up to 24 months with a budget of $1,000,000 for advancing projects into production. Interested parties must submit their proposals by January 8, 2025, and can find more information at the DLA's SBIR website.
    Language Models for Veteran Suicide Prevention (LM4VSP) -
    Active
    DOD
    The Department of Defense, through DARPA, is seeking proposals for the Language Models for Veteran Suicide Prevention (LM4VSP) initiative, which aims to develop a conversational AI clinical co-pilot to assist mental health care professionals in supporting veterans at risk of suicide. The project focuses on leveraging advancements in natural language processing to provide continuous assistance, particularly during critical times when traditional support may be limited, addressing the pressing public health crisis of veteran suicide. This initiative is structured in two phases: Phase I involves feasibility studies and proof-of-concept development, while Phase II aims to create a prototype capable of generating accurate responses and evaluating its efficacy. The solicitation is set to open on December 4, 2024, with proposals due by January 8, 2025, and further details can be found at the provided source link.
    Ferrimagnetic Shocklines for a Solid-State High-Power Microwave System -
    Active
    DOD
    The Department of Defense (DoD) is soliciting proposals for the development of ferrimagnetic shocklines aimed at enhancing high-voltage pulse sharpening capabilities in solid-state high-power microwave systems. The initiative seeks innovative solutions that improve size, weight, and power (SWaP) while enabling the sharpening of high-voltage impulses exceeding 100 kVs, with specific performance targets of 150 picoseconds rise times and 500 picoseconds pulse widths. This project is critical for advancing military technology in directed energy and microelectronics, aligning with modernization priorities. Proposals are due by January 8, 2025, and interested parties can find more information on the DoD SBIR website.
    Secure Wireless Data Transfer Solutions for Predictive Logistics -
    Active
    DOD
    The Department of Defense, specifically the Army, is seeking innovative solutions for secure wireless data transfer to enhance Predictive Logistics within military operations. The objective is to develop a technology that enables real-time transmission of logistics data from Digital Source Collectors (DSCs) on Tactical Wheeled Vehicles to a centralized collection point, thereby improving the monitoring of vehicle health, fuel, and ammunition levels for Unit Commanders and Maintainers. This initiative is crucial for modernizing military logistics and operational efficiency, with potential applications extending to various sectors such as logistics management, predictive maintenance, and emergency services. Interested parties can submit proposals for Phase I, with funding up to $250,000 for six months or up to $1.999 million for 24 months, with the application deadline set for January 8, 2025. For more information, visit the official solicitation page at https://www.dodsbirsttr.mil/topics-app/.
    Engaging the Manufacturing Industrial Base in Support of DLA’s Critical Supply Chains -
    Active
    DOD
    The Defense Logistics Agency (DLA) is launching an initiative under the Small Business Innovation Research (SBIR) program titled "Engaging the Manufacturing Industrial Base in Support of DLA’s Critical Supply Chains." This opportunity aims to enhance the manufacturing base by developing qualified sources of supply, fostering competition, and addressing lifecycle performance issues through collaboration with DLA program managers and engineering support activities. The program consists of two phases: Phase I, which has a budget of $100,000 over 12 months for qualifying sources, and an optional Phase II, allowing up to $1,000,000 over 24 months for further development based on Phase I performance. Interested small businesses must have JCP certification to access technical data and are encouraged to submit proposals by the application deadline of January 8, 2025. For more information, visit the DLA SBIR website at https://www.dodsbirsttr.mil/topics-app/.
    Large Language Models for System Security Engineering Analysis -
    Active
    DOD
    The Department of Defense (DoD) is seeking proposals for the development of a specialized Large Language Model (LLM) aimed at enhancing cybersecurity for aviation and missile systems, addressing vulnerabilities from both traditional and AI-based threats. The primary objective is to create a tool that assists assessment teams in identifying and modeling vulnerabilities, thereby providing critical inputs for both blue and red teams within the DoD. This initiative is crucial for improving the cyber resilience of weapon systems during their development phase, ultimately enhancing their operational effectiveness against sophisticated cyber threats. Interested parties can submit Phase I proposals with a funding cap of $250,000 for a six-month period, with the application due by January 8, 2025. For more details, visit the solicitation agency's website at https://www.dodsbirsttr.mil/topics-app/.
    3.3/5V Configurable Logic ASIC -
    Active
    DOD
    The Department of Defense (DoD) is seeking proposals for the development of a U.S.-sourced, 3.3/5V configurable logic application-specific integrated circuit (ASIC) to address the growing issue of electronics obsolescence. The objective is to create a solution that can be adapted to various integrated circuit packages, supporting both combinational and sequential logic designs, while ensuring compatibility with existing 3.3V and 5V systems. This initiative is critical for maintaining the reliability and longevity of defense electronics systems, as the global defense electronics obsolescence market is projected to reach $3.7 billion by 2028. Interested parties should note that the solicitation is set to open on December 4, 2024, with proposals due by January 8, 2025, and can find more information at the DoD SBIR/STTR website.
    DIRECT TO PHASE II: Accelerator-Based Launcher for Shipboard Systems -
    Active
    DOD
    The Department of Defense, specifically the United States Navy, is seeking proposals for the development of a Direct to Phase II Accelerator-Based Launcher for shipboard systems aimed at enhancing unmanned aerial vehicle (UAV) deployment capabilities. The objective is to create a shipboard launching system that can release group 1-2 UAVs at speeds exceeding Mach 1, achieving deployment distances greater than 70 km without utilizing onboard fuel, thereby extending operational range and payload capacity for intelligence, surveillance, reconnaissance (ISR), or anti-submarine warfare (ASW) missions. This innovative system is expected to address current limitations of traditional launching systems, which are constrained by fuel dependency and large footprints, thus improving mission flexibility and ship capacity. Proposals are due by February 5, 2025, with the opportunity being pre-released on December 4, 2024. Interested parties can find more information and submit proposals through the official SBIR website at https://www.dodsbirsttr.mil/topics-app/.