The Department of Health and Human Services, specifically the National Institutes of Health, is seeking proposals for addressing health inequities in clinical diagnostics through their Small Business Innovation Research (SBIR) program. The purpose of this funding opportunity is to encourage small businesses to develop improved or alternative clinical diagnostics that address health disparities created by clinical laboratory assays and point-of-care devices that fail to incorporate diverse patient groups. The goal is to develop clinical diagnostics that are accessible to populations that experience health disparities and to eliminate health inequities. The research objectives include developing clinical diagnostics that meet or exceed the quality of existing diagnostics, considering social determinants of health during the development process, and including input from relevant populations that experience health disparities. The funding opportunity accepts various types of projects, such as novel technologies addressing known issues in existing diagnostics, projects addressing health inequities in analytics or bioinformatics, and pilot or small-scale projects validating new technology. The funding is available for both Phase I and Phase II projects, with the option for a Fast Track application. The National Institute of Arthritis and Musculoskeletal and Skin Diseases, the Sexual & Gender Minority Research Office, and the National Human Genome Research Institute are also participating in this funding opportunity.