The Department of Health and Human Services, specifically the National Institutes of Health, is seeking proposals for addressing health inequities in clinical diagnostics through their Small Business Innovation Research (SBIR) program. The purpose of this funding opportunity is to encourage small businesses to develop improved or alternative clinical diagnostics that incorporate diverse patient groups and address health disparities. The goal is to lay the groundwork for more equitable clinical diagnostics that lead to improved health, healthcare delivery, and the elimination of health disparities. The research objectives include developing clinical diagnostics that are accessible to populations that experience health disparities, considering social determinants of health during the development process, and including input from relevant populations. The funding opportunity accepts various types of projects, such as novel technologies addressing known issues in existing diagnostics, projects addressing health disparities in analytics or bioinformatics, and pilot or small-scale projects validating new technology. The funding is divided into different phases, including Phase I to establish technical feasibility and Phase II for further development and commercialization. The National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) and the Sexual & Gender Minority Research Office (SGMRO) are also participating in this funding opportunity, each with their specific research priorities. The National Human Genome Research Institute (NHGRI) encourages comprehensive genomics research with commercial potential. The solicitation is currently open, with multiple application due dates throughout the year. For more information, refer to the solicitation agency URL provided.