Novel Technologies for CWMD and Related Threats - Open Topic
ID: DTRA254-P005Type: BOTH
Overview

Topic

Novel Technologies for CWMD and Related Threats - Open Topic

Agency

Agency: DODBranch: DTRA

Program

Type: SBIRPhase: BOTH
Timeline
    Description

    The Defense Threat Reduction Agency (DTRA) is seeking innovative solutions through its Small Business Innovation Research (SBIR) program to enhance the detection of weapons of mass destruction (WMD) and related threats. The objective is to develop novel technologies that utilize existing general-purpose military hardware or commercially available devices to detect WMD threats without relying on specialized sensors. This initiative is crucial for improving national security capabilities in a landscape where the commercial market for detection equipment is limited. The opportunity includes multiple phases: Phase I focuses on identifying feasible use cases and developing a proof of concept, while Phase II involves building and testing a prototype. The solicitation is currently in the pre-release stage, with an open date of January 7, 2026, and a close date of January 28, 2026. Interested parties can find more information and apply through the DOD SBIR website.

    Files
    Title
    Posted
    DTRA254-P005 is an open topic Request for Proposal (RFP) seeking novel technologies to detect radiological or nuclear threats without specialized sensors. The objective is to utilize signals from existing general-purpose military hardware, commercial devices, and publicly available data. This initiative aims to overcome challenges associated with developing new military hardware and the limited commercial market for WMD detection equipment. The RFP is divided into three phases: Phase I focuses on identifying a feasible use case and developing a course of action for prototyping; Phase II involves building and testing a model or prototype; and Phase III refines the technology for broader defense, governmental, and commercial applications. The technology developed under this topic is subject to International Traffic in Arms Regulation (ITAR) and Export Administration Regulation (EAR) restrictions.
    DTRA254-P005 is an open topic Request for Proposal (RFP) from the Defense Threat Reduction Agency (DTRA) seeking novel technologies for detecting radiological or nuclear threats. The objective is to develop solutions that utilize signals from existing general-purpose military hardware, commercially available devices, and public data sources, rather than bespoke sensors. This initiative aims to overcome challenges associated with the cost and time of developing new military hardware for WMD detection, particularly given the limited commercial market for specialized equipment. The technology is subject to ITAR and EAR regulations, requiring disclosure of foreign national involvement. Phase I focuses on identifying a feasible use case and developing a course of action for prototyping. Phase II involves building and testing a model or prototype. Phase III aims to refine the technology for broader defense, governmental, and commercial dual-use applications.
    The DTRA254-P005 Open Topic seeks novel technologies for detecting radiological and nuclear threats without specialized sensors. Instead, it proposes using signals from existing general-purpose military hardware, commercial devices, and publicly available data sources. The initiative aims to overcome challenges associated with the cost and time required to develop new military hardware for WMD detection, especially given the limited commercial market for such equipment. The project is structured in three phases: Phase I focuses on identifying feasible use cases and developing a course of action for prototyping; Phase II involves building and testing a model or prototype; and Phase III refines the technology for broader defense, governmental, and commercial applications. This technology is subject to ITAR/EAR restrictions, requiring disclosure of foreign national involvement.
    DTRA254-P005 is an open topic Request for Proposal (RFP) from the Department of Defense's Defense Threat Reduction Agency (DTRA) seeking novel technologies for detecting Weapons of Mass Destruction (WMD) and related threats. The objective is to develop solutions that can identify radiological or nuclear threats using existing general-purpose military hardware, commercial devices, and publicly available data, rather than specialized WMD sensors. The RFP emphasizes solutions with both commercial and national security applications. The project is structured in three phases: Phase I focuses on identifying a feasible use case and developing a course of action for a prototype; Phase II involves building and testing a model or prototype; and Phase III refines the technology for broader defense, governmental, and commercial dual-use applications. This technology is subject to International Traffic in Arms Regulation (ITAR) and Export Administration Regulation (EAR) controls.
    DTRA254-P005 is an open topic Request for Proposal (RFP) seeking novel technologies for the detection and warning of radiological or nuclear threats. The objective is to utilize existing general-purpose military hardware, commercially available devices, and publicly available data sources to detect Weapons of Mass Destruction (WMD) without requiring specialized sensors. This initiative aims to overcome challenges associated with the timelines and costs of developing new military hardware and the limited commercial market for WMD detection equipment. The RFP is divided into three phases: Phase I focuses on identifying feasible use cases and developing a course of action for prototyping; Phase II involves building and testing a prototype or model; and Phase III refines the technology for broader defense, governmental, and commercial applications. The technology developed under this topic is subject to International Traffic in Arms Regulation (ITAR) and Export Administration Regulation (EAR).
    DTRA254-P005 is an open topic Request for Proposal (RFP) from the Defense Threat Reduction Agency (DTRA) seeking novel technologies for detecting radiological or nuclear threats. The objective is to develop solutions that utilize signals from general-purpose military hardware, commercially available devices, and publicly available data sources, eliminating the need for specialized WMD sensors. This initiative addresses the challenges of developing and producing new military hardware for WMD detection. Phase I focuses on identifying feasible use cases and developing a course of action for prototyping. Phase II involves building and testing a model or prototype. Phase III aims to refine the technology for broader applicability, including dual-use applications for defense, government, and commercial sectors. The technology is subject to ITAR and EAR regulations, requiring disclosure of foreign national involvement.
    The DTRA254-P005 Open Topic seeks novel technologies for detecting Weapons of Mass Destruction (WMD) and related threats without specialized sensors. The objective is to utilize signals from general-purpose military hardware, commercial devices, and publicly available data sources for detection of radiological or nuclear threats. This initiative aims to overcome challenges associated with the timelines and costs of developing new military hardware for WMD detection, particularly given the limited commercial market for such equipment. The project is structured in three phases: Phase I will identify feasible use cases and propose a development course; Phase II will focus on building and testing a model or prototype; and Phase III will refine the technology for broader defense, governmental, and commercial applications. The technology is subject to International Traffic in Arms Regulation (ITAR) and Export Administration Regulation (EAR).
    DTRA254-P005 is an open topic Request for Proposal (RFP) from the Defense Threat Reduction Agency (DTRA) seeking novel technologies for detecting Weapons of Mass Destruction (WMD) and related threats. The objective is to develop solutions that can detect radiological or nuclear threats using existing general-purpose military hardware, commercially available devices, and publicly available data sources, rather than specialized WMD sensors. The RFP emphasizes technologies applicable to chemical, biological, nuclear, and radiological defense. It outlines a three-phase development process: Phase I focuses on identifying feasible use cases and proposing a development course; Phase II involves building and testing a model or prototype; and Phase III refines the technology for broader defense, governmental, and commercial dual-use applications. This initiative aims to overcome challenges associated with the cost and timeline of developing new military hardware for WMD detection, especially given the limited commercial market for such equipment. The technology developed under this topic is subject to International Traffic in Arms Regulations (ITAR) and Export Administration Regulations (EAR), requiring disclosure of any foreign national involvement.
    DTRA254-P005 is an open topic Request for Proposal (RFP) from the Defense Threat Reduction Agency (DTRA) seeking novel technologies for the detection of Weapons of Mass Destruction (WMD) and related threats. The objective is to develop solutions that can detect radiological, nuclear, chemical, and biological threats using signals from existing general-purpose military hardware, commercially available devices, and publicly available data sources, rather than bespoke sensors. This initiative aims to overcome challenges associated with the timelines and costs of developing new military hardware and the limited commercial market for WMD detection equipment. The RFP outlines a three-phase development process: Phase I focuses on identifying feasible use cases and developing a course of action for a prototype; Phase II involves building and testing a model or prototype; and Phase III refines the technology for broader defense, governmental, and commercial dual-use applications. The technology developed under this topic is subject to International Traffic in Arms Regulation (ITAR) and Export Administration Regulation (EAR) restrictions.
    The DTRA254-P005 "Novel Technologies for CWMD and Related Threats - Open Topic" seeks innovative solutions for detecting radiological or nuclear threats without specialized sensors. This initiative, part of federal government RFPs, aims to leverage signals from general-purpose military hardware, commercial devices, and public data sources to overcome challenges associated with developing new WMD detection equipment. The project is restricted under ITAR and EAR regulations, requiring disclosure of foreign national involvement. Phase I focuses on identifying feasible use cases and developing a course of action for prototyping. Phase II involves building and testing a model or prototype to detect WMDs. Phase III will refine the technology for broader mission support and explore dual-use applications for defense, governmental, and commercial sectors. This effort by the Department of Defense aims to enhance Joint Force capabilities in deterring, detecting, and defeating weapons of mass destruction.
    DTRA254-P005 is an open topic Request for Proposal (RFP) from the Defense Threat Reduction Agency (DTRA) seeking novel technologies for detecting radiological or nuclear threats. The objective is to develop solutions that utilize signals from existing general-purpose military hardware, commercially available devices, or publicly available data sources, rather than requiring specialized sensors. This initiative aims to overcome challenges associated with the timelines and costs of developing new military hardware for WMD detection. The RFP is divided into three phases: Phase I focuses on identifying feasible use cases and proposing a development course of action; Phase II involves building a model or prototype to test the proposed technology; and Phase III refines the technology for broader mission support and explores dual-use applications for defense, governmental, and commercial sectors. The technology is restricted under ITAR/EAR regulations, requiring disclosure of foreign national involvement.
    DTRA254-P005 is an open topic Request for Proposal (RFP) from the Defense Threat Reduction Agency (DTRA) seeking novel technologies for detecting radiological or nuclear threats. The objective is to develop solutions that utilize existing general-purpose military hardware, commercial devices, and publicly available data sources for detection, rather than specialized sensors. This initiative aims to overcome challenges associated with the cost and timelines of developing new military hardware and the limited commercial market for WMD detection equipment. The RFP outlines three phases: Phase I focuses on identifying feasible use cases and developing a course of action; Phase II involves building a model or prototype for testing; and Phase III refines the technology for broader defense, governmental, and commercial applications. The technology developed under this topic is subject to International Traffic in Arms Regulation (ITAR) and Export Administration Regulation (EAR).
    The DTRA254-P005 Open Topic seeks novel technologies for detecting radiological and nuclear threats without specialized sensors, utilizing signals from existing general-purpose military hardware, commercial devices, and public data. This initiative aims to overcome challenges associated with the cost and timeline of developing new military hardware for WMD detection. The project is structured in three phases: Phase I focuses on identifying feasible use cases and developing a course of action; Phase II involves building and testing a model or prototype; and Phase III refines the technology for broader defense, governmental, and commercial dual-use applications. The technology is subject to ITAR and EAR regulations, requiring disclosure of any foreign national involvement.
    The DTRA254-P005
    Please provide the text you would like summarized.
    Similar Opportunities
    Integrated Deployable Microsensors for Chemical Detection -
    DOD
    The Department of Defense (DoD) is seeking proposals for the development of integrated deployable microsensors for chemical detection under the SBIR program, specifically identified as CBD254-007. The objective is to design and fabricate low Size, Weight, Power, and Cost (SWaP-C) microsensors capable of detecting chemical warfare agents and pharmaceutical-based agents in vapor and aerosol forms, providing near real-time early warning in complex operational environments. This technology is crucial for enhancing rapid response and decision-making in both military and civilian applications, particularly for first responders in environmental detection and health monitoring. Proposals are due by January 28, 2026, with the opportunity opening on January 7, 2026, and further details can be found at the official solicitation agency website: https://www.dodsbirsttr.mil/topics-app/.
    Far Forward Manufacturing of CBRN Sensors -
    DOD
    The Department of Defense is seeking proposals for the Far Forward Manufacturing (FFM) of Chemical, Biological, Radiological, and Nuclear (CBRN) sensors, aimed at enhancing the production capabilities of these critical technologies. The objective is to accelerate the development of sensors that are minimal in size, weight, and power consumption while enabling near real-time detection and transmission of threat information to warfighters, thereby reducing reliance on complex supply chains. This initiative is vital for ensuring force readiness and adaptability in modern warfare, with potential applications extending beyond the military to commercial sectors such as clinical diagnostics and environmental sensing. Interested parties should note that the solicitation is currently in the pre-release phase, with proposals due by January 28, 2026, and further details can be found at the provided source link: https://www.dodsbirsttr.mil/topics-app/.
    Novel Sampling Tickets for Surface Enhanced Raman Spectroscopy (SERS) of Chemical and Biological (CB) Threat Materials -
    DOD
    The Department of Defense (DOD) is seeking innovative solutions for the development of novel sampling tickets designed for Surface Enhanced Raman Spectroscopy (SERS) to detect chemical and biological threat materials. The objective is to create physically semi-porous, flexible coupons that can enhance the sensitivity and selectivity of handheld Raman detectors, which currently require bulk samples and struggle with mixtures of materials. This initiative is crucial for improving the capabilities of fielded handheld Raman spectrometers, enabling them to detect trace amounts of hazardous substances such as toxins and fentanyl analogs from various surfaces. The solicitation is currently in the pre-release phase, with proposals due by January 28, 2026, and further details can be found at the DOD SBIR website.
    OPEN TOPIC - Tactical CB Visualization -
    DOD
    The Department of Defense (DOD) is seeking innovative solutions through the SBIR program to enhance situational awareness and decision support for Warfighters operating in Chemical and Biological (CB) contested environments. The objective is to develop a tactical visualization tool or capability that integrates with Mission Oriented Protective Posture (MOPP) kits and various respirators, focusing on Human-Machine Interface (HMI) concepts to improve size, weight, and power (SWAP) demands. This opportunity is critical for ensuring effective communication and data visualization in dynamic battlefield scenarios, with potential dual-use applications in civilian sectors such as emergency response and manufacturing. Interested parties should note that the solicitation is set to open on January 7, 2026, with proposals due by January 28, 2026, and can find more information at the DOD SBIR website.
    Unbiased Behavioral Discovery Platforms -
    DOD
    The Department of Defense (DoD), through the Defense Advanced Research Projects Agency (DARPA), is seeking innovative solutions for the development of unbiased behavioral discovery platforms aimed at enhancing the detection and development of medical countermeasures against chemical, biological, radiological, and nuclear (CBRN) threats. The primary objective is to create automated, high-throughput technologies that can quantify novel animal behaviors in preclinical models, thereby improving the sensitivity and specificity of behavioral evaluations without requiring human annotation or invasive procedures. This initiative is critical for advancing defense health capabilities and ensuring rapid response to emerging threats, with a focus on ethical considerations and minimizing animal handling. The opportunity is currently in the pre-release phase, with applications opening on January 7, 2026, and closing on January 28, 2026. Interested parties can find more information and submit proposals through the official SBIR website.
    Microphysiological systems to Assess Pretreatment Immunogenicity and Efficacy (MAGPIE) -
    DOD
    The Defense Threat Reduction Agency (DTRA) is seeking proposals for the development of Microphysiological Systems (MPS) to assess pretreatment immunogenicity and efficacy for vaccines against high-consequence pathogens, under the SBIR program. The primary objective is to create immune microphysiological systems (iMPS) that can accurately model human immune responses in vitro, thereby accelerating the discovery and validation of medical countermeasures essential for warfighter readiness. This initiative addresses the limitations of traditional in vitro and in vivo models, which are often slow and do not fully replicate the complexity of the human immune system, ultimately hindering rapid vaccine development. Interested parties should note that the solicitation is currently in the pre-release phase, with the open date set for January 7, 2026, and the application due date on January 28, 2026. For more information, please visit the official solicitation link at https://www.dodsbirsttr.mil/topics-app/.
    Affordable IR Sensors for Proliferated LEO Missile Tracking Constellation -
    DOD
    The United States Space Force (USSF), through the Space Development Agency (SDA), is seeking proposals for the development of affordable, high-performance midwave infrared (MWIR) sensor technologies as part of the SF254-D1207 project. The objective is to create innovative sensor solutions that can detect and track missile threats in Low Earth Orbit (LEO) while significantly reducing costs and complexity, with a focus on radiation tolerance, small satellite compatibility, and efficient manufacturing processes. These sensors are critical for the Proliferated Warfighter Space Architecture (PWSA) and other missile warning constellations, enhancing national security capabilities. Interested applicants must submit their proposals by January 28, 2026, with the opportunity being pre-released on September 3, 2025, and further details available at the official solicitation agency website.
    Silencing with Acoustic Rainbow Emitters (SWARE) -
    DOD
    The Department of Defense, specifically the Special Operations Command (SOCOM), is seeking innovative research and development proposals for a low-cost Acoustic Rainbow Emitter (ARE) designed for Unmanned Aerial Systems (UAS). The primary objective is to significantly reduce and redirect the acoustic signature of UAS, achieving at least a 50% reduction in noise levels, while ensuring the sound emitted is inaudible to humans and directed away from the ground. This technology is crucial for enhancing the stealth capabilities of Special Operations Forces during tactical operations in non-permissive environments. Interested parties should note that the solicitation number is SOCOM254-008, with a release date of September 3, 2025, and the application window opening on January 7, 2026, and closing on January 28, 2026. For more details, visit the official source link at https://www.dodsbirsttr.mil/topics-app/.
    OPEN TOPIC - Expeditionary Biologics-on-Demand (BOND) -
    DOD
    The Department of Defense (DOD) is seeking proposals for the Small Business Innovation Research (SBIR) program focused on the development of an OPEN TOPIC - Expeditionary Biologics-on-Demand (BOND) system. The primary objective is to create a portable, high-performance system for on-demand protein production that maximizes purity, potency, and quality through advanced automation and machine learning techniques. This initiative aims to enhance supply chain resilience and medical countermeasure capabilities by enabling localized production of diverse biologics, including therapies and vaccines, particularly in forward-deployed locations. The solicitation is currently in pre-release status, with an open date of January 7, 2026, and a close date of January 28, 2026. Interested parties can find more information and submit proposals through the DOD SBIR website at https://www.dodsbirsttr.mil/topics-app/.
    Complex Geometries for Extended Wear Respirators Towards Regenerable Particulate Matter Protection -
    DOD
    The Department of Defense (DOD) is seeking innovative solutions through the Small Business Innovation Research (SBIR) program to develop a rugged, 3D-printable, PFAS-free particulate filtration impactor system for extended-wear respirators in military environments. The objective is to create a regenerable filtration system that can be easily manufactured at the point of need, attach to existing respirators (such as the M50 and commercial half-masks), and effectively trap aerosols while minimizing breathing resistance and clogging during high aerobic activity. This initiative addresses the significant health risks posed by high levels of airborne particulate matter (PM10 and PM2.5) that military personnel face, particularly in operational environments. Interested parties should note that the solicitation is currently in pre-release, with the open date set for January 7, 2026, and the application due date on January 28, 2026. For more information, visit the DOD SBIR website at https://www.dodsbirsttr.mil/topics-app/.