The Department of Defense, through the Defense Advanced Research Projects Agency (DARPA), is seeking proposals for the development of a Direct Blood Oxygenation Titration System (D-BOTS) aimed at enhancing prolonged field care for combat casualties suffering from acute lung injury (ALI) and acute respiratory distress syndrome (ARDS). The primary objective is to create a portable, automated, closed-loop system that delivers oxygen directly to the bloodstream via a small-diameter intravascular catheter, maintaining a specified level of blood oxygen saturation without requiring continuous manual intervention. This initiative is critical given the increasing incidence of ARDS in combat scenarios, particularly in remote locations where access to medical care is limited, and aims to reduce mortality rates and complications associated with ALI and ARDS. Proposals are due by October 22, 2024, and interested parties can find more information and submit their applications through the official DARPA SBIR website.